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TargetN-acylethanolamine-hydrolyzing acid amidase (NAAA)
LigandBDBM50439663
Substrate/Competitorn/a
Meas. Tech.Enzymatic Assay
pH7.4±n/a
IC50 1170±n/a nM
Commentsextracted
Citation Piomelli, DBandiera, TMor, MTarzia, GBertozzi, FPonzano, S Disubstituted beta-lactones as inhibitors of N-acylethanolamine acid amidase (NAAA) US Patent US9353075 Publication Date 5/31/2016
More Info.:Get all data from this article,  Assay Method
 
N-acylethanolamine-hydrolyzing acid amidase (NAAA)
Name:N-acylethanolamine-hydrolyzing acid amidase (NAAA)
Synonyms:ASAH-like protein | Asahl | N-acylethanolamine acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase | N-acylethanolamine-hydrolyzing acid amidase subunit alpha | N-acylethanolamine-hydrolyzing acid amidase subunit beta | N-acylsphingosine amidohydrolase-like | Naaa
Type:Enzyme
Mol. Mass.:40306.53
Organism:Rattus norvegicus (Rat)
Description:Q5KTC7
Residue:362
Sequence:
MGTPAIRAACHGAHLALALLLLLSLSDPWLWATAPGTPPLFNVSLDAAPELRWLPMLQHY
DPDFVRAAVAQVIGDRVPQWILEMIGEIVQKVESFLPQPFTSEIRGICDYLNLSLAEGVL
VNLAYEASAFCTSIVAQDSQGRIYHGRNLDYPFGNALRKLTADVQFVKNGQIVFTATTFV
GYVGLWTGQSPHKFTISGDERDKGWWWENMIAALSLGHSPISWLIRKTLTESEDFEAAVY
TLAKTPLIADVYYIVGGTSPQEGVVITRDRGGPADIWPLDPLNGAWFRVETNYDHWEPVP
KRDDRRTPAIKALNATGQAHLSLETLFQVLSVFPVYNNYTIYTTVMSAAEPDKYMTMIRN
PS
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  Blast E-value cutoff:
BDBM50439663
NameBDBM50439663
Synonyms:CHEMBL2419823 | US9353075, 34
TypeSmall organic molecule
Emp. Form.C17H23NO4
Mol. Mass.305.3688
SMILESC[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCCc1ccccc1 |r|
Structure
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n/a