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Target
Cytochrome P450 11B2, mitochondrial
Ligand
BDBM233868
Substrate
n/a
Meas. Tech.
Cellular Enzyme Assay
Temperature
310.15±n/a K
EC50
5.3±n/a nM
Comments
extracted
Citation
 Aebi, J; Amrein, K; Fantasia, SM; Hornsperger, B; Kuhn, B; Liu, Y; Maerki, HP; Mayweg, AV; Mohr, P; Scalone, M; Tan, X; Zhou, M Bicyclic dihydroquinoline-2-one derivatives US Patent  US9353081 Publication Date 5/31/2016 
Target
Name:
Cytochrome P450 11B2, mitochondrial
Synonyms:
Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase
Type:
Protein
Mol. Mass.:
57582.15
Organism:
Homo sapiens (Human)
Description:
P19099
Residue:
503
Sequence:
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN
  
Inhibitor
Name:
BDBM233868
Synonyms:
US9353081, 62
Type:
Small organic molecule
Emp. Form.:
C25H23ClN4O2
Mol. Mass.:
446.929
SMILES:
CN1C(=O)CCc2cc(ccc12)-c1cncc2[C@@H](CCCc12)NC(=O)c1ncccc1Cl |r|
Structure:
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