Reaction Details Report a problem with these data
Target
Plasmepsin II
Ligand
BDBM234531
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
4.5±n/a
Temperature
298.15±n/a K
IC50
12.3±n/a nM
Comments
extracted
Citation
 Chen, X; Ding, K; Meyers, MJ; Tortorella, MD; Xu, J Compositions and methods for the treatment of malaria US Patent  US9353089 Publication Date 5/31/2016 
Target
Name:
Plasmepsin II
Synonyms:
Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II
Type:
Enzyme
Mol. Mass.:
51482.09
Organism:
Plasmodium falciparum
Description:
P46925
Residue:
453
Sequence:
MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYENVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKTNYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
  
Inhibitor
Name:
BDBM234531
Synonyms:
US9353089, 212
Type:
Small organic molecule
Emp. Form.:
C27H27N3O
Mol. Mass.:
409.5228
SMILES:
N=C1NC(C(=O)N1C1CCCCC1)(c1ccccc1)c1cccc(c1)-c1ccccc1
Structure:
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