Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM50335803
Substrate
n/a
Meas. Tech.
Bla2 Activity Assay
pH
7±n/a
IC50
3.67e+5±n/a nM
Comments
extracted
Citation
 Schlesinger, SR; Bruner, B; Farmer, PJ; Kim, SK Kinetic characterization of a slow-binding inhibitor of Bla2: thiomaltol. J Enzyme Inhib Med Chem 28:137-42 (2013) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
BAS3245 | Beta-lactamase (Bla2) | Beta-lactamase II | GBAA_3500 | bla2
Type:
Enzyme
Mol. Mass.:
28177.23
Organism:
Bacillus anthracis
Description:
Q93T40
Residue:
256
Sequence:
MKNTLLKLGVCVSLLGITPFVSTISSVQAERKVEHKVIKNETGTISISQLNKNVWVHTELGYFNGEAVPSNGLILNTSKGLVLVDSSWDDKLTKELIEMAEKKFKKSVTDVIITHAHADRIGGIKTLKERGIKAHSTTLTAELAKKNGYEEPLGDLQAITKLKFGNMKVETFYPGKGHTEDNIVVWLPQYNMLVGGCLVKSASAKDLGNITDAYVNEWSTSIENVLKRYENINFVVPGHGEVGDKGLLLHTLDLLK
  
Inhibitor
Name:
BDBM50335803
Synonyms:
3-hydroxy-2-methyl-4H-pyran-4-thione | CHEMBL1650615 | Thiomaltol
Type:
Small organic molecule
Emp. Form.:
C6H6O2S
Mol. Mass.:
142.176
SMILES:
Cc1occc(=S)c1O
Structure:
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