Reaction Details Report a problem with these data
Target
Glycogen synthase kinase-3 beta
Ligand
BDBM293647
Substrate
n/a
Meas. Tech.
GSK3 beta kinase assay
Temperature
298.15±n/a K
EC50
3.00±n/a nM
Comments
extracted
Citation
KC, SK; Mak, CC; Eastman, BW; Cao, J; Bollu, V; Mittapalli, GK; Chiruta, C Isoquinolin-3-yl carboxamides and preparation and use thereof US Patent US10106527 Publication Date 10/23/2018
More Info.:
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
Inhibitor
Name:
BDBM293647
Synonyms:
US10106527, Compound 445 | US10544128, Compound 445 | US11548872, Compound 445 | US20230286945, Compound 445 | US9951048, Compound 445
Type:
Small organic molecule
Emp. Form.:
C24H26N8O
Mol. Mass.:
442.5162
SMILES:
CN1CCN(CC1)c1cc(CC(=O)Nc2cc3cc(ccc3cn2)-c2cn(C)nn2)ccn1