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TargetAcid ceramidase (AC)
LigandBDBM50431246
Substrate/Competitorn/a
Meas. Tech.Enzymatic Assay
IC50 7±n/a nM
Citation Piomelli, DRealini, NMor, MPagliuca, CPizzirani, DScarpelli, RBandiera, T Acid ceramidase inhibitors and their use as medicaments US Patent US9428465 Publication Date 8/30/2016
More Info.:Get all data from this article,  Assay Method
 
Acid ceramidase (AC)
Name:Acid ceramidase (AC)
Synonyms:AC | ACDase | Acid CDase | Acid ceramidase | Acylsphingosine deacylase | Asah1 | N-acylsphingosine amidohydrolase
Type:Enzyme
Mol. Mass.:44450.22
Organism:Rattus norvegicus (Rat)
Description:Q6P7S1
Residue:394
Sequence:
MLGRSLLTWVLAAAVTCAQAQQVPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYKR
WHELLAHKAPVLRTLVNSISNLVNAFVPSGKIMQMVDEKLPGLIGSIPGPFGEEMRGIAD
VTGIPLGEIISFNIFYELFTMCTSIITEDGKGHLLHGRNMDFGIFLGWNINNNTWVVTEE
LKPLTVNLDFQRNNKTVFKATSFAGYVGMLTGFKPGLLSLTLNERFSLNGGYLGILEWMF
GKKNAQWVGFITRSVLENSTSYEEAKNILTKTKITAPAYFILGGNQSGEGCVITRERKES
LDVYELDPKHGRWYVVQTNYDRWKNTLFLDDRRTPAKKCLNHTTQKNLSFATIYDVLSTK
PVLNKLTVFTTLIDVTKDQFESHLRDCPDPCIGW
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50431246
NameBDBM50431246
Synonyms:CHEMBL2333062 | US9428465, 32
TypeSmall organic molecule
Emp. Form.C14H20F3N3O3
Mol. Mass.335.3221
SMILESCCCCCCCCNC(=O)n1cc(c(=O)[nH]c1=O)C(F)(F)F
Structure
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