Reaction Details Report a problem with these data
Target
Interstitial collagenase [100-268]
Ligand
BDBM7462
Substrate
n/a
Meas. Tech.
cd-MMP-1 Activity Assay
pH
7.5±n/a
IC50
1.35e+3±n/a nM
Comments
extracted
Citation
 Lu, W; Zhu, J; Zou, S; Li, X; Huang, J The efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors. J Enzyme Inhib Med Chem 28:741-6 (2013) [PubMed]  Article 
Target
Name:
Interstitial collagenase [100-268]
Synonyms:
CLG | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 (cd-MMP-1)
Type:
Enzyme
Mol. Mass.:
18886.85
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human MMP-1 (100-268 aa)
Residue:
169
Sequence:
FVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQ
  
Inhibitor
Name:
BDBM7462
Synonyms:
3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-chromen-4-one | CHEMBL150 | Kaempferol (18) | Kaempferol (Kmp) | cid_5280863 | kaempferol
Type:
Small organic molecule
Emp. Form.:
C15H10O6
Mol. Mass.:
286.2363
SMILES:
Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Structure:
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