Reaction Details Report a problem with these data
Target
Interstitial collagenase [100-268]
Ligand
BDBM26658
Substrate
n/a
Meas. Tech.
cd-MMP-1 Activity Assay
pH
7.5±n/a
IC50
4.85e+3±n/a nM
Comments
extracted
Citation
 Lu, W; Zhu, J; Zou, S; Li, X; Huang, J The efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors. J Enzyme Inhib Med Chem 28:741-6 (2013) [PubMed]  Article 
Target
Name:
Interstitial collagenase [100-268]
Synonyms:
CLG | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 (cd-MMP-1)
Type:
Enzyme
Mol. Mass.:
18886.85
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human MMP-1 (100-268 aa)
Residue:
169
Sequence:
FVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQ
  
Inhibitor
Name:
BDBM26658
Synonyms:
2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopyran-4-one | 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one | 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone | 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one | 2-[2,4-bis(oxidanyl)phenyl]-3,5,7-tris(oxidanyl)chromen-4-one | CHEMBL28626 | MLS000069618 | Morin (19) | Morin (5) | Morin (Mor) | SMR000058259 | cid_5281670 | morin
Type:
Flavonoid
Emp. Form.:
C15H10O7
Mol. Mass.:
302.2357
SMILES:
Oc1ccc(c(O)c1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Structure:
Search PDB for entries with ligand similarity: