Reaction Details Report a problem with these data
Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM6504
Substrate
cdc2 substrate peptide
Meas. Tech.
Kinase inhibition Assay
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
63±n/a nM
Citation
 Wang, YD; Miller, K; Boschelli, DH; Ye, F; Wu, B; Floyd, MB; Powell, DW; Wissner, A; Weber, JM; Boschelli, F Inhibitors of src tyrosine kinase: the preparation and structure-activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines. Bioorg Med Chem Lett 10:2477-80 (2000) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM6504
Synonyms:
4-Anilino-3-cyanoquinoline deriv. 7a | 4-[(4-ethoxy-3,5-dimethoxyphenyl)amino]-6,7-dimethoxyquinoline-3-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C22H23N3O5
Mol. Mass.:
409.4351
SMILES:
CCOc1c(OC)cc(Nc2c(cnc3cc(OC)c(OC)cc23)C#N)cc1OC
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
cdc2 substrate peptide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
358.43
Organism:
n/a
Description:
100 uM ATP as co-substrate
Residue:
3
Sequence:
NA