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Target
Coagulation factor X
Ligand
BDBM294043
Substrate
n/a
Meas. Tech.
Rat Coagulation Factor Xa Assay
pH
8.3±n/a
Ki
21.5±n/a nM
Comments
extracted
Citation
 Chen, S; Ding, Z; Gong, G; Yan, X; Huang, W; Guo, F; Duan, B; Gao, R; Zhou, P; Lu, X; Dong, G Preparation method for benzoxazoleoxazine ketone compound and intermediate and crystal form thereof US Patent  US10106557 Publication Date 10/23/2018 
Target
Name:
Coagulation factor X
Synonyms:
Coagulation factor X precursor | F10 | FA10_RAT | Factor Xa (fXa) | Stuart factor
Type:
Enzyme
Mol. Mass.:
54255.03
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
482
Sequence:
MESPVRLSLLYVVLASLLLPGRSVFINRERANNVLQRIRRANSFFEEIKKGNLERECVEEICSFEEAREVFEDNEKTTEFWNKYEDGDQCESSPCQNQGECRDGLGSYTCTCTEGFEGKNCELFVRKLCSLDNGDCDQFCREEQNSVVCSCAKGYFLGNDGKSCLSTAPFPCGKTNKGRAKRSVALNTSNSEPDPEDLMPDADILYPTESPSELLNLNKTEPEANSDDVIRIVGGQECKRGECPWQALLFSDEETDGFCGGTILNEFYILTAAHCLHQAKRFKVRVGDLNTEQEDGGEMVHEVDMIIKHNKFQRDTYDFDIAMLRLKTPITFRENVAPACLPQKDWAEATLMTQKTGIVSGFGRTHEKGRQSKVLKMMEVPYVDRNTCRLSTSFSITQNMFCAGYDAKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKARVGPTSETPRLTHPPY
  
Inhibitor
Name:
BDBM294043
Synonyms:
US10106557, Compound 30
Type:
Small organic molecule
Emp. Form.:
C22H24ClN3O5S
Mol. Mass.:
477.961
SMILES:
COC[C@H]1CCCN1c1ccc2N3[C@@H](COc2c1)[C@H](CNC(=O)c1ccc(Cl)s1)OC3=O |r|
Structure:
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