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Target
Complement factor D
Ligand
BDBM249390
Substrate
n/a
Meas. Tech.
In Vitro Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
6±n/a nM
Comments
extracted
Citation
 Flohr, S; Hommel, U; Lorthiois, EL; Maibaum, JK; Ostermann, N; Quancard, J; Randl, SA; Rogel, O; Vulpetti, A Pyrrolidine derivatives and their use as complement pathway modulators US Patent  US9464081 Publication Date 10/11/2016 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM249390
Synonyms:
US9464081, 22
Type:
Small organic molecule
Emp. Form.:
C22H26FN5O3
Mol. Mass.:
427.4719
SMILES:
[#6]-[#6@@H](-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6@H]-2-[#6]-[#6@H]-2-[#7]-1-[#6](=O)-[#6]-n1nc(-[#6](-[#7])=O)c2ccccc12)-[#6](\F)=[#6](\[#6])-[#6] |r|
Structure:
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