Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 4
Ligand
BDBM249441
Substrate
FGFR1 substrate peptide
Meas. Tech.
Kinase HotSpot Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
<1±n/a nM
Comments
extracted
Citation
Reynolds, D; Hao, M; Wang, J; Prajapati, S; Satoh, T; Selvaraj, A Pyrimidine FGFR4 inhibitors US Patent US9434697 Publication Date 9/6/2016
More Info.:
Target
Name:
Fibroblast growth factor receptor 4
Synonyms:
CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF
Type:
Protein
Mol. Mass.:
87957.45
Organism:
Homo sapiens (Human)
Description:
P22455
Residue:
802
Sequence:
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
Inhibitor
Name:
BDBM249441
Synonyms:
US10537571, Compound 162 | US10912774, Compound 162 | US9434697, 162 | US9730931, Compound 162
Type:
Small organic molecule
Emp. Form.:
C23H21Cl2FN6O4
Mol. Mass.:
535.355
SMILES:
COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(F)cccc3NC(=O)C=C)ncn2)c1Cl
Substrate
Name:
FGFR1 substrate peptide
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
1596.80
Organism:
Artificial Organism
Description:
SEQ ID NO:1
Residue:
14
Sequence:
KKKSPGEYVNIEFG