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Target
Hematopoietic prostaglandin D synthase
Ligand
BDBM250506
Substrate
n/a
Meas. Tech.
Enzyme Immunoassay (EIA) Assay
pH
7.4±n/a
IC50
12±n/a nM
Comments
extracted
Citation
 Vandeusen, CL; Weiberth, FJ; Gill, HS; Lee, G; Hillegass, A Phenyloxadiazole derivatives as PGDS inhibitors US Patent  US9469627 Publication Date 10/18/2016 
Target
Name:
Hematopoietic prostaglandin D synthase
Synonyms:
GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase
Type:
Enzyme
Mol. Mass.:
23341.07
Organism:
Homo sapiens (Human)
Description:
The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:
199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL
  
Inhibitor
Name:
BDBM250506
Synonyms:
US9469627, 1
Type:
Small organic molecule
Emp. Form.:
C22H20N6O3
Mol. Mass.:
416.4326
SMILES:
CC(C)(O)c1nc(no1)-c1cccc(CNC(=O)c2cnc(nc2)-c2ccccn2)c1
Structure:
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