Reaction Details Report a problem with these data
Target
Lysophosphatidic acid receptor 5
Ligand
BDBM251671
Substrate
n/a
Meas. Tech.
Receptor Assay
Temperature
310.15±n/a K
IC50
31±n/a nM
Comments
extracted
Citation
 Buffham, W; Canning, H; Davenport, R; Farnaby, W; Mack, S; Parmar, A; Wright, S Compounds US Patent  US9464060 Publication Date 10/11/2016 
Target
Name:
Lysophosphatidic acid receptor 5
Synonyms:
GPR92 | GPR93 | LPAR5 | LPAR5_HUMAN | Lysophosphatidic acid receptor 5 | Lysophosphatidic acid receptor 5 (LPA5)
Type:
Enzyme
Mol. Mass.:
41372.36
Organism:
Homo sapiens (Human)
Description:
Q9H1C0
Residue:
372
Sequence:
MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSLSSFTQCPQDSAL
  
Inhibitor
Name:
BDBM251671
Synonyms:
US10100018, Example 7 | US9464060, 7
Type:
Small organic molecule
Emp. Form.:
C27H26FNO5
Mol. Mass.:
463.4974
SMILES:
COC1CC(CN(Cc2ccc(cc2)C(O)=O)C(=O)c2ccc(Oc3ccccc3F)cc2)C1 |(4.67,6.48,;3.33,5.71,;3.33,4.17,;4.42,3.08,;3.33,1.99,;3.33,.45,;2,-.32,;2,-1.86,;3.33,-2.63,;3.33,-4.17,;4.67,-4.94,;6,-4.17,;6,-2.63,;4.67,-1.86,;7.34,-4.94,;7.34,-6.48,;8.67,-4.17,;.67,.45,;.67,1.99,;-.67,-.32,;-.67,-1.86,;-2,-2.63,;-3.33,-1.86,;-4.67,-2.63,;-6,-1.86,;-6,-.32,;-7.34,.45,;-8.67,-.32,;-8.67,-1.86,;-7.34,-2.63,;-7.34,-4.17,;-3.33,-.32,;-2,.45,;2.25,3.08,)|
Structure:
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