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TargetCDK2/CycE
LigandBDBM6676
Substrate/CompetitorING Peptide
Meas. Tech.CDK Kinase Inhibition Assay
Temperature298.15±n/a K
IC50 324±n/a nM
Commentsextracted
Citation Jaramillo, C; de Diego, JE; Hamdouchi, C; Collins, E; Keyser, H; Sanchez-Martinez, C; del Prado, M; Norman, B; Brooks, HB; Watkins, SA; Spencer, CD; Dempsey, JA; Anderson, BD; Campbell, RM; Leggett, T; Patel, B; Schultz, RM; Espinosa, J; Vieth, M; Zhang, F; Timm, DE Aminoimidazo[1,2-a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation. Bioorg Med Chem Lett14:6095-9 (2004) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
CDK2/CycE
Name:CDK2/CycE
Synonyms:CDK2/Cyclin E | CDK2/E | CDK2/E1 | Cyclin-Dependent Kinase 2 (CDK2) | Cyclin-dependent kinase 2/G1/S-specific cyclin E1 | Cyclin-dependent kinase 2/cyclin E1
Type:Protein
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Protein cereblon/Cyclin-dependent kinase 2
Synonyms:CDK2 | CDK2-Kinase | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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  Blast E-value cutoff:
Component 2
Name:G1/S-specific cyclin-E1
Synonyms:CCNE | CCNE1
Type:Enzyme Subunit
Mol. Mass.:47073.17
Organism:Homo sapiens (Human)
Description:n/a
Residue:410
Sequence:
MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQ
PWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIM
LNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQ
ENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWR
LSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILA
ASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNI
QTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA
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  Blast E-value cutoff:
BDBM6676
NameBDBM6676
Synonyms:3-benzoyl-6-[(2,6-difluorophenyl)carbonyl]imidazo[1,2-a]pyridin-2-amine | aminoimidazo[1,2-a]pyridine deriv. 13
TypeSmall organic molecule
Emp. Form.C21H13F2N3O2
Mol. Mass.377.3436
SMILESNc1nc2ccc(cn2c1C(=O)c1ccccc1)C(=O)c1c(F)cccc1F
Structure
ING Peptide
Name:ING Peptide
Synonyms:n/a
Type:Peptide
Mol. Mass.:1341.50
Organism:n/a
Description:amino acid residues 246-257 from human retinoblastoma 1 protein.
Residue:12
Sequence:
ingsprtprrgq