Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM294297
Substrate
n/a
Meas. Tech.
IMAP Technology
pH
7.2±n/a
IC50
196±n/a nM
Comments
extracted
Citation
 Seganish, WMHanisak, JLi, GZhang, RTang, H Inhibitors of IRAK4 activity US Patent  US9586948 Publication Date 3/7/2017
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM294297
Synonyms:
US9586948, Example 16
Type:
Small organic molecule
Emp. Form.:
C18H17F2N7O2
Mol. Mass.:
401.3701
SMILES:
Cn1cc(NC(=O)c2cccc(n2)-c2ccnc(NCC(F)F)c2)c(n1)C(N)=O
Structure:
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