Reaction Details Report a problem with these data
Target
Poly [ADP-ribose] polymerase tankyrase-2 [946-1162]
Ligand
BDBM259528
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
0.389±n/a nM
Citation
 Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, X Quinazolinone compounds and derivatives thereof US Patent  US9505749 Publication Date 11/29/2016 
Target
Name:
Poly [ADP-ribose] polymerase tankyrase-2 [946-1162]
Synonyms:
PARP5B | TANK2 | TNKL | TNKS2 | TNKS2_HUMAN | Tankyrase-2
Type:
Enzyme
Mol. Mass.:
24581.05
Organism:
Homo sapiens (Human)
Description:
aa 946-1162
Residue:
217
Sequence:
LNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEG
  
Inhibitor
Name:
BDBM259528
Synonyms:
US9505749, 39
Type:
Small organic molecule
Emp. Form.:
C23H21N5O3S
Mol. Mass.:
447.51
SMILES:
O=C(CCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1C[C@H](C1)c1nnc(o1)-c1ccccc1 |r,wU:17.18,19.23,(-1.01,-.23,;-1.41,-1.72,;-2.9,-2.11,;-3.98,-1.03,;-5.47,-1.42,;-6.56,-.34,;-8.05,-.73,;-9.14,.36,;-10.63,-.04,;-11.71,1.05,;-11.32,2.53,;-9.83,2.93,;-8.74,1.84,;-7.25,2.24,;-6.85,3.73,;-6.16,1.15,;-.32,-2.8,;1.17,-2.41,;1.94,-1.07,;3.27,-1.84,;2.5,-3.18,;4.76,-1.44,;5.24,.02,;6.78,.02,;7.25,-1.44,;6.01,-2.35,;8.74,-1.84,;9.83,-.75,;11.32,-1.15,;11.71,-2.64,;10.63,-3.73,;9.14,-3.33,)|
Structure:
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