Reaction Details Report a problem with these data
Target
Poly [ADP-ribose] polymerase tankyrase-2 [946-1162]
Ligand
BDBM259567
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
0.434±n/a nM
Citation
 Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, X Quinazolinone compounds and derivatives thereof US Patent  US9505749 Publication Date 11/29/2016 
Target
Name:
Poly [ADP-ribose] polymerase tankyrase-2 [946-1162]
Synonyms:
PARP5B | TANK2 | TNKL | TNKS2 | TNKS2_HUMAN | Tankyrase-2
Type:
Enzyme
Mol. Mass.:
24581.05
Organism:
Homo sapiens (Human)
Description:
aa 946-1162
Residue:
217
Sequence:
LNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEG
  
Inhibitor
Name:
BDBM259567
Synonyms:
US9505749, 78
Type:
Small organic molecule
Emp. Form.:
C25H26N4O3
Mol. Mass.:
430.4989
SMILES:
O=C(CCCc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@@H](CC1)Oc1ccc(cc1)C#N |r,wU:17.18,wD:20.25,(-1.33,.39,;-1.33,-1.15,;-2.67,-1.92,;-4,-1.15,;-5.33,-1.92,;-6.67,-1.15,;-8,-1.92,;-9.34,-1.15,;-10.67,-1.92,;-12,-1.15,;-12,.39,;-10.67,1.16,;-9.34,.39,;-8,1.16,;-8,2.7,;-6.67,.39,;,-1.92,;1.33,-1.15,;1.33,.39,;2.67,1.16,;4,.39,;4,-1.15,;2.67,-1.93,;5.33,1.15,;6.67,.38,;6.67,-1.16,;8,-1.93,;9.34,-1.16,;9.34,.38,;8,1.15,;10.67,-1.93,;12,-2.7,)|
Structure:
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