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Target
D-amino-acid oxidase
Ligand
BDBM406236
Substrate
n/a
Meas. Tech.
In Vitro Measurements of porcine D-Amino Acid Oxidase (DAAO) Activities
IC50
55.0±n/a nM
Citation
 Tsai, GE; Wang, C; Hsieh, Y D-amino acid oxidase inhibitors and therapeutic uses thereof US Patent  US10336724 Publication Date 7/2/2019 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-Amino Acid Oxidase (DAAO) | D-amino-acid oxidase (DAAO) | DAMOX | DAO | OXDA_PIG
Type:
Flavoprotein
Mol. Mass.:
39338.01
Organism:
Sus scrofa (pig)
Description:
Homodimer.
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPYIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFRPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNLLTMPPSHL
  
Inhibitor
Name:
BDBM406236
Synonyms:
US10336724, Compound Table 1.16
Type:
Small organic molecule
Emp. Form.:
C27H21ClN4O3
Mol. Mass.:
484.934
SMILES:
Clc1ccccc1CCc1cc([nH]n1)C(=O)Oc1cc(Cc2cccc3ccccc23)n[nH]c1=O
Structure:
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