Reaction Details Report a problem with these data
Target
Epoxide hydrolase
Ligand
BDBM50342208
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
2.00±n/a nM
Citation
 Guedes, AG; Hammock, BD; Morisseau, C Treatment of inflammatory disorders in non-human mammals US Patent  US10383835 Publication Date 8/20/2019 
Target
Name:
Epoxide hydrolase
Synonyms:
EPHX1
Type:
Enzyme
Mol. Mass.:
52112.47
Organism:
Ovis aries (Sheep)
Description:
W5Q7Q6
Residue:
451
Sequence:
MWLEILLASVLGFVIYWFVSKDKEETLPLEDGWWGPGVRPTAGEDKSIRPFKVETSDEEINDLHQRIDRVRLTPPLEDSRFHYGFNSNYLKKIISYWRNEFDWRKQVEILNKYPHFKTKIEGLDIHFIHVKPPNLPSGQTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQKFYIQGGDWGALICTNMAQLVPSHIKGLHLNMALILRNFYTLTLPLGRCFGGLFGYTERDMELIYPFKKIFFSLLRESGYMHIQSTKPDTVGCALNDSPVGLAAYILEKFSTWTNSEFRDLEDGGLERKFSLDDLLTGIMLYWTTGTITSSQRFYKENLAQVNKHETLKVYVPTGFAAFPCELIHSPEKWVKTKYPKLISYSYMPRGGHFAAFEEPELLAQDIRKFVGLQERQ
  
Inhibitor
Name:
BDBM50342208
Synonyms:
4-{3-[3-(3-Cycloheptyl-ureido)-propyl]-5-phenyl-pyrazol-1-yl}-benzenesulfonamide | CHEMBL1766285 | US10383835, Compound 2247
Type:
Small organic molecule
Emp. Form.:
C26H33N5O3S
Mol. Mass.:
495.637
SMILES:
NS(=O)(=O)c1ccc(cc1)-n1nc(CCCNC(=O)NC2CCCCCC2)cc1-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: