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Target
Non-receptor tyrosine-protein kinase TYK2 [888-1187]
Ligand
BDBM103727
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.5±n/a
IC50
780±n/a nM
Comments
extracted
Citation
 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Substituted indazoles for treating tendon and/or ligament injuries US Patent  US10112907 Publication Date 10/30/2018 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [888-1187]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (aa 888-1187) | TYK2 | TYK2 (aa 888-1187) | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
34527.73
Organism:
Homo sapiens (Human)
Description:
P29597[888-1187]
Residue:
300
Sequence:
DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
  
Inhibitor
Name:
BDBM103727
Synonyms:
US10112907, Example 00033 | US10206907, Compound 200 | US10708263, Compound 1 | US10766894, Compound TABLE 1.18 | US10919890, Compound 1 | US10961228, Example Filgotinib | US11000528, Cpd # 1 | US11203595, TABLE 1.18 | US11279699, Compound Filgotinib | US8563545, 1
Type:
Small organic molecule
Emp. Form.:
C21H23N5O3S
Mol. Mass.:
425.504
SMILES:
O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1
Structure:
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