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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM374430
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
550±n/a nM
Citation
 Chan, T; Guckian, K; Jenkins, T; Thomas, J; Vessels, J; Kumaravel, G; Meissner, R; Lyssikatos, J; Lucas, B; Leaf, I; Duffield, J IRAK4 inhibiting agents US Patent  US10577367 Publication Date 3/3/2020 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM374430
Synonyms:
5-(1-(4-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine | US10246456, Example 39 | US10577367, Example 39
Type:
Small organic molecule
Emp. Form.:
C18H15N5
Mol. Mass.:
301.3452
SMILES:
Cc1ccnc(c1)-n1ncc2ccc(cc12)-c1cncc(N)c1
Structure:
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