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TargetTyrosine-protein kinase BTK
LigandBDBM165583
Substrate/Competitorn/a
Meas. Tech.Btk Enzyme Assay
IC50 0.12±n/a nM
Citation Liu, QWatterson, SHAhmad, S Indole carboxamide compounds US Patent US9688629 Publication Date 6/27/2017
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase BTK
Name:Tyrosine-protein kinase BTK
Synonyms:ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK | Tyrosine-protein kinase BTK (BTK)
Type:Enzyme
Mol. Mass.:76289.95
Organism:Homo sapiens (human)
Description:Q06187
Residue:659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM165583
NameBDBM165583
Synonyms:US9688629, 194 | US9688629, 195 | US9688629, 196
TypeSmall organic molecule
Emp. Form.C22H20FN3O2S
Mol. Mass.409.477
SMILESCc1[nH]c2c(cc(F)c(-c3cccc4N(CCSc34)C(=O)C=C)c2c1C)C(N)=O |(-5.29,2.31,;-3.75,2.31,;-2.84,3.56,;-1.38,3.08,;-.05,3.85,;1.29,3.08,;1.29,1.54,;2.62,.77,;-.05,.77,;-.05,-.77,;-1.38,-1.54,;-1.38,-3.08,;-.05,-3.85,;1.29,-3.08,;2.62,-3.85,;3.96,-3.08,;3.96,-1.54,;2.62,-.77,;1.29,-1.54,;2.62,-5.39,;1.29,-6.16,;3.96,-6.16,;5.29,-5.39,;-1.38,1.54,;-2.84,1.06,;-3.3,-.27,;-.05,5.39,;1.29,6.16,;-1.38,6.16,)|
Structure
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