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TargetE3 ubiquitin-protein ligase Mdm2
LigandBDBM215165
Substrate/Competitorn/a
Meas. Tech.Homogenous Time-Resolved Fluorescence Assay (HTRF1 Assay)
IC50 390±n/a nM
Citation Bartberger, MDGonzalez Buenrostro, ABeck, HPChen, XConnors, RVDeignan, JDuquette, JAEksterowicz, JFisher, BFox, BMFu, JFu, ZGonzalez Lopez De Turiso, FGribble, Jr., MWGustin, DJHeath, JAHuang, XJiao, XJohnson, MGKayser, FKopecky, DJLai, SLi, YLi, ZLiu, JLow, JDLucas, BSMa, ZMcGee, LRMcIntosh, JMcMinn, DLMedina, JCMihalic, JTOlson, SHRew, YRoveto, PMSun, DWang, XWang, YYan, XYu, MZhu, J Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer US Patent US9593129 Publication Date 3/14/2017  Article
More Info.:Get all data from this article,  Assay Method
 
E3 ubiquitin-protein ligase Mdm2
Name:E3 ubiquitin-protein ligase Mdm2
Synonyms:E3 ubiquitin-protein ligase Mdm2 (aa 1-188)
Type:n/a
Mol. Mass.:21319.18
Organism:Homo sapiens (Human)
Description:n/a
Residue:188
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM215165
NameBDBM215165
Synonyms:US9296736, 116 | US9593129, Example 116
TypeSmall organic molecule
Emp. Form.C27H29Cl2NO3
Mol. Mass.486.43
SMILESC[C@@]1(CC(O)=O)C[C@@H](C(N(C(C2CC2)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1 |r|
Structure
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n/a