Reaction Details Report a problem with these data
Target
Beta-casein
Ligand
BDBM7781
Substrate
stathmin
Meas. Tech.
Kinase Inhibition Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
>100000±n/a nM
Citation
 Martinez, A; Alonso, M; Castro, A; Perez, C; Moreno, FJ First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J Med Chem 45:1292-9 (2002) [PubMed]  Article 
Target
Name:
Beta-casein
Synonyms:
Antioxidant peptide | Beta-casein | CASB_BOVIN | CK II | CSN2 | Casein Kinase II | Casohypotensin | Casoparan
Type:
Enzyme Mixture
Mol. Mass.:
25102.49
Organism:
Bos taurus (bovine)
Description:
The purified enzyme from bovine brains shows three major bands with apparent molecular masses of 42, 38, and 27 kDa by polyacrylamide gel electrophoresis in sodium dodecyl sulfate.
Residue:
224
Sequence:
MKVLILACLVALALARELEELNVPGEIVESLSSSEESITRINKKIEKFQSEEQQQTEDELQDKIHPFAQTQSLVYPFPGPIPNSLPQNIPPLTQTPVVVPPFLQPEVMGVSKVKEAMAPKHKEMPFPKYPVEPFTESQSLTLTDVENLHLPLPLLQSWMHQPHQPLPPTVMFPPQSVLSLSQSKVLPVPQKAVPYPQRDMPIQAFLLYQEPVLGPVRGPFPIIV
  
Inhibitor
Name:
BDBM7781
Synonyms:
4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione | NP 01139 | TDZD-8 | Thiadiazolidinone (TDZD) deriv. 8 | US20230414581, Compound 1
Type:
Small organic molecule
Emp. Form.:
C10H10N2O2S
Mol. Mass.:
222.264
SMILES:
Cn1sc(=O)n(Cc2ccccc2)c1=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
stathmin
Synonyms:
Leukemia-associated phosphoprotein p18 | Metablastin | Phosphoprotein p19
Type:
Other Protein Type
Mol. Mass.:
17169.10
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
148
Sequence:
ASSDIQVKELEKRASGQAFELILSPRSKESVPEFPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKLERLREKDKHIEEVRKNKESKDPADETEAD