Assay Method Information

Assay Name:  Electrophysiology Assay
Description:  Compounds were tested using a PatchXpress (Model 7000A, Molecular Devices, Union City Calif.) on CHO cells over-expressing h KCa3.1 at ChanTest Corporation, 14656 Neo Parkway, Cleveland, Ohio.The compounds I of the present invention exhibit IC50 values in the patch clamp assay of 10 nM to 10 μM, preferably 10 nM to 1 μM for patch clamp.
Affinity data for this assay
 

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