Assay Method Information

Assay Name:  QFRET-based biochemical high throughput dose response assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2)
Description:  Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provider: Michael H. Gelb, University of Washington Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number R37HL036235 Grant Proposal PI: Michael H. Gelb, University of Washington External Assay ID: HGIII-SPLA2_INH_QFRET_1536_3XIC50 DRUN Name: QFRET-based biochemical high throughput dose response assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2). Description: Phospholipases A2 (PLA2s) are a class of enzymes that hydrolyze the sn-2 ester of glycerophospholipids to release a free fatty acid and a lysophospholipid [1]. Secreted PLA2s (sPLA2s) have been implicated in the pathogenesis of inflammatory disease in humans. Inhibitors of many of the sPLA2s in the human and mouse genome have been made, but to date no inhibitor of human group III sPLA2 (hGIII-sPLA2) has been
Affinity data for this assay
 

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