Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) for PDB: 1HNN
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  120nMAssay Description:Binding affinity to wild type human PNMT by liquid scintillation spectrometry in presence of [3H]AdoMetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  120nMAssay Description:Binding affinity to human wild type his-tagged PNMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  280nM ΔG°:  -38.9kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  280nMAssay Description:Inhibitory binding affinity for phenylethanolamine N-methyl-transferase (PNMT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  280nMAssay Description:Inhibition of [3H]methyl-AdoMet binding to human phenylethanolamine N-methyl-transferase expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  280nMAssay Description:In vitro binding affinity against human phenylethanolamine N-MethyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  280nMAssay Description:Inhibitory activity against human PNMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  280nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  580nMAssay Description:Inhibitory constant against human phenylethanolamine N-methyl-transferase over-expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  2.84E+3nMAssay Description:Binding affinity to human free PNMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)