Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) for PDB: 1ISS
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50030627BDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataKi:  165nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50030627BDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50030627BDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Emory University

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50030627BDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50030627BDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Emory University

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50030627BDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Emory University

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50030627BDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataKi:  5.00E+4nMAssay Description:Binding affinity towards mGluR1a was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Emory University

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50030627BDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataIC50: 1.55E+5nMAssay Description:Inhibitory concentration for half maximal inhibition of PI hydrolysis (mGluR1a)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Emory University

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50030627BDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataIC50: 1.55E+5nMAssay Description:Ability to inhibit mGluR1-alpha-mediated PI (phospho inositol) hydrolysis was determined at BHK cells at 100 Micro M ConcentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Emory University

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50030627BDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataKi:  5.40E+5nMAssay Description:Agonist potency against cloned human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Emory University

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50030627BDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataIC50: 7.00E+5nMAssay Description:Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article
PDB3D3D Structure (crystal)