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Found 7 Enz. Inhib. hit(s) for PDB: 1K21
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289562(CHEMBL3216390 | CHEMBL543774 | {(R)-1-Cyclohexylme...)
Affinity DataKi:  3nMAssay Description:Selective inhibition of thrombin in several in vitro and in vivo models of thrombosisMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...)
Affinity DataKi:  15nMAssay Description:Binding affinity against Thrombin.Checked by AuthorMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...)
Affinity DataKi:  15nMAssay Description:The inhibitory activity of the compound was tested against thrombin (IIa)More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289562(CHEMBL3216390 | CHEMBL543774 | {(R)-1-Cyclohexylme...)
Affinity DataKi:  15nMAssay Description:Inhibition of thrombin was evaulatedMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...)
Affinity DataIC50:  17nMAssay Description:Inhibition against platelet aggregation without interacting directly with the nucleophilic serine of thrombin.Checked by AuthorMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of thrombin (IIa)More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...)
Affinity DataIC50:  2.24E+4nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair