Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) for PDB: 1RR6
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKd:  0.0580nMAssay Description:Binding affinity to human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Bovine)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKd:  0.0230nMAssay Description:Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKd:  0.0560nMAssay Description:Inhibition of human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of human recombinant PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human PNP activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataIC50: 57nMAssay Description:Inhibition of human recombinant PNP expressed in Escherichia coli incubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human purine nucleoside phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  0.0560nMAssay Description:Equilibrium dissociation constant determined against human purine nucleoside phosphorylase (PNP) after slow-onset inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  0.0560nMAssay Description:Dissociation constant against Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  0.0560nMAssay Description:Inhibitory activity of compound against human purine nucleoside phosphorylase (PNP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  0.0560nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  0.0579nMAssay Description:Equilibrium binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human PNP activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of human purine nucleoside phosphorylase; Initial rate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity towards Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  3.30nMAssay Description:Initial binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Bovine)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  41nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 50 mM inor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  72nMAssay Description:Inhibition of human PNP assessed as inhibitor constant for enzyme-inhibitor-substrate complex formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)