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Report error Found 26 Enz. Inhib. hit(s) for PDB: 1UH5

Enoyl-acyl carrier reductase(malaria parasite P. falciparum)
Bombay College of Pharmacy

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

IC50: 49nMpH: 7.4Assay Description:Inhibition assay using pfENR.More data for this Ligand-Target Pair

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Date in BDB:
7/1/2013
Entry Details Article
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
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Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

IC50: 66nMAssay Description:Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cellsMore data for this Ligand-Target Pair

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Date in BDB:
12/10/2012
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
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Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

IC50: 70nMAssay Description:Inhibition of Plasmodium falciparum recombinant FabIMore data for this Ligand-Target Pair

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Date in BDB:
1/11/2010
Entry Details Article
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
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Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

IC50: 70nMAssay Description:Inhibition of Plasmodium falciparum enoyl-ACP reductase assessed as oxidation of NADH to NAD+ after 10 mins by spectrophotometric analysisMore data for this Ligand-Target Pair

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Date in BDB:
7/22/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
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Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

IC50: 73nMAssay Description:Inhibition of Plasmodium falciparum ENR enzymatic activityMore data for this Ligand-Target Pair

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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
Institute of Science

Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

IC50: 73nMAssay Description:Inhibition of Plasmodium falciparum enoyl-acyl carrier protein reductaseMore data for this Ligand-Target Pair

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Date in BDB:
8/26/2010
Entry Details Article
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3D Structure (crystal)

Enoyl-ACP reductase(malaria parasite P. falciparum)
Jacobus Pharmaceutical

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

IC50: 73nMpH: 7.9 T: 2°CAssay Description:PfENR inhibition assays were carried out on a Cary 100 Bio Spectrophotometer or POLARstar Optima by monitoring oxidation of NADH at 340 nm. The IC50 ...More data for this Ligand-Target Pair

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Date in BDB:
11/11/2008
Entry Details Article
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
Institute of Science

Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

IC50: 73nMAssay Description:Inhibition of PfENR enzymatic activityMore data for this Ligand-Target Pair

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Date in BDB:
11/10/2009
Entry Details Article
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3D Structure (crystal)

Enoyl-ACP reductase(malaria parasite P. falciparum)
Jacobus Pharmaceutical

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

IC50: 200nMAssay Description:Inhibition of Plasmodium falciparum Enoyl-ACP reductase using crotonyl-CoA as substrate peincubated for 5 mins measured after 10 mins of substrate ad...More data for this Ligand-Target Pair

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Date in BDB:
3/23/2012
Entry Details Article
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
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Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

Ki: 0.00190nMAssay Description:Inhibition of Plasmodium falciparum ENR in presence of EGCG by dilution assayMore data for this Ligand-Target Pair

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Date in BDB:
12/9/2012
Entry Details Article
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
Institute of Science

Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

Ki: 0.0521nMAssay Description:Inhibition of Plasmodium falciparum ENR in presence of ECG by dilution assayMore data for this Ligand-Target Pair

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Date in BDB:
12/9/2012
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
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Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

Ki: 0.109nMAssay Description:Inhibition of Plasmodium falciparum ENR in presence of EGC by dilution assayMore data for this Ligand-Target Pair

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Date in BDB:
12/9/2012
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
Institute of Science

Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

Ki: 0.281nMAssay Description:Inhibition of Plasmodium falciparum ENR in presence of quercetin by dilution assayMore data for this Ligand-Target Pair

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Date in BDB:
12/9/2012
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
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Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

Ki: 0.798nMAssay Description:Inhibition of Plasmodium falciparum ENR in presence of butein by dilution assayMore data for this Ligand-Target Pair

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Date in BDB:
12/9/2012
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
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Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

Ki: 1nMAssay Description:Inhibition of Plasmodium falciparum ENR in presence of EGCGMore data for this Ligand-Target Pair

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Date in BDB:
12/9/2012
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
Institute of Science

Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

Ki: 7.29nMAssay Description:Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of EGCGMore data for this Ligand-Target Pair

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Date in BDB:
12/9/2012
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
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Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

Ki: 8nMAssay Description:Inhibition of Plasmodium falciparum ENR in presence of ECGMore data for this Ligand-Target Pair

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Date in BDB:
12/9/2012
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
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Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

Ki: 8.25nMAssay Description:Inhibition of Plasmodium falciparum ENR in presence of EGCMore data for this Ligand-Target Pair

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Date in BDB:
12/9/2012
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
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Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

Ki: 10nMAssay Description:Inhibition of Plasmodium falciparum ENR in presence of quercetinMore data for this Ligand-Target Pair

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Date in BDB:
12/9/2012
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
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Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

Ki: 13.7nMAssay Description:Inhibition of Plasmodium falciparum ENR in presence of buteinMore data for this Ligand-Target Pair

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Date in BDB:
12/9/2012
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
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Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

Ki: 28.3nMAssay Description:Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of ECGMore data for this Ligand-Target Pair

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Date in BDB:
12/9/2012
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
Institute of Science

Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

Ki: 30.5nMAssay Description:Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of quercetinMore data for this Ligand-Target Pair

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Date in BDB:
12/9/2012
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
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Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

Ki: 50nMAssay Description:Inhibition of Plasmodium falciparum enoyl-acyl carrier protein reductase expressed in Escherichia coli BL21(DE3) by spectrophotometryMore data for this Ligand-Target Pair

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Date in BDB:
8/26/2010
Entry Details Article
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
Institute of Science

Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

Ki: 52.7nMAssay Description:Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of EGCMore data for this Ligand-Target Pair

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Date in BDB:
12/9/2012
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
Institute of Science

Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

Ki: 71.0nMAssay Description:Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of buteinMore data for this Ligand-Target Pair

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Date in BDB:
12/9/2012
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3D Structure (crystal)

Enoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
Institute of Science

Curated by ChEMBL

BDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)

Ki: 660nMAssay Description:Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to crotonyl CoAMore data for this Ligand-Target Pair

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Date in BDB:
12/10/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Filter my 26 hits

Targets 3▿
- Enoyl-acyl-carrier protein reductase 23
- Enoyl-ACP reductase 2
- Enoyl-acyl carrier reductase 1
Publications 10▿
- J Med Chem 50: 765-75 (2007) 15
- Eur J Med Chem 44: 3009-19 (2009) 2
- J Med Chem 50: 2665-75 (2007) 2
- Antimicrob Agents Chemother 51: 2552-8 (2007) 1
- J Nat Prod 74: 1370-8 (2011) 1
- Bioorg Med Chem Lett 16: 2163-9 (2006) 1
- Bioorg Med Chem Lett 22: 610-2 (2011) 1
- Bioorg Med Chem Lett 15: 5247-52 (2005) 1
- Chem Biol Drug Des 81: 715-29 (2013) 1
- J Biol Chem 282: 25436-44 (2007) 1
Institutions 7▿
- National Institute of Immunology 15
- Institute of Science 3
- Jacobus Pharmaceutical 3
- International Centre For Science and High Technology 2
- University of Karachi 1
- Bombay College of Pharmacy 1
- University of Yaounde 1
Affinity: 0.0019 to 6.6E+2 nM▿
- Ki 17
- IC50 9
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1