Affinity DataEC50: 359nMAssay Description:Agonist activity at GAL4-tagged human LXRalpha assessed as receptor activation expressed in African green monkey CV1 cells by luciferase reporter gen...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 85nMAssay Description:Agonist activity at human LXRalpha expressed in human SH-SY5Y cells co-transfected with Gal4-LBD after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 400nMAssay Description:Agonist activity at human LXRalpha transfected in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Agonist activity at LXRalpha (unknown origin) expressed in human HepG2 cells co-expressing ABCA1 promoter measured after 48 hrs by cell-based transac...More data for this Ligand-Target Pair
Affinity DataEC50: 91nMAssay Description:Agonist activity at human LXRalpha-LBD assessed as recruitment of co-activator peptide after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 135nMAssay Description:Agonist activity at human LXRalpha ligand binding domain (205-448) expressed in human HuH7 cells co-transfected with Gal4-DBD by luciferase transacti...More data for this Ligand-Target Pair
Affinity DataEC50: 140nMAssay Description:Displacement of [3H]TO901317 from human recombinant LXRalpha expressed in Escherichia coli by flashplate methodMore data for this Ligand-Target Pair
Affinity DataEC50: 340nMAssay Description:Transactivational agonist activity at human LXRalpha transfected in HEK293 cells expressing CMX-Gal4N assessed as luciferase activity after 16 hrs by...More data for this Ligand-Target Pair
Affinity DataEC50: 373nMAssay Description:Agonist activity at GAL4-fused human LXRalpha expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dua...More data for this Ligand-Target Pair
Affinity DataEC50: 1.43E+3nMAssay Description:Agonist activity at human LXR-alpha assessed as increase in recruitment of Trap 220/Drip2 coactivator peptide by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 63nMAssay Description:Agonist activity at LXRalpha ligand binding domain-mediated transcriptional activity in african green monkey CV1 cells co-transfected with Gal4-SRC1 ...More data for this Ligand-Target Pair
Affinity DataEC50: 3.20nMAssay Description:Agonist activity at LXRalpha by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 940nMAssay Description:Partial agonist activity at recombinant human GAL4-DBD-fused LXRalpha-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo lucifera...More data for this Ligand-Target Pair
Affinity DataEC50: 490nMAssay Description:Agonist activity at GAL4 fused LXRalpha (unknown origin) transfected in CHOK1 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Agonist activity at human LXRalpha expressed in HEK293 cells co-expressing CMX-beta-galactosidase incubated for 16 hrs by luciferase reporter gene as...More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:As used herein, reference to the activity of an LXR agonist at LXRα and LXRβ refer to the activity as measured using the ligand sensing ass...More data for this Ligand-Target Pair
Affinity DataEC50: 190nMAssay Description:Agonist activity at Homo sapiens (human) LXRalpha expressed in HepG2 cells assessed as transactivation of CYP7A1 gene expression after 48 hr by lucif...More data for this Ligand-Target Pair
Affinity DataEC50: 530nMAssay Description:Transactivation of recombinant GAL4-fused human LXRalpha LBD (163 to 447 residues) expressed in human L02 cells measured after 24 hrs by luciferase r...More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Agonist activity LXRalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Agonist activity LXRalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:As used herein, reference to the activity of an LXR agonist at LXRα and LXRβ refer to the activity as measured using the ligand sensing ass...More data for this Ligand-Target Pair
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataEC50: 0.0980nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataEC50: 0.108nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 260nMAssay Description:Agonist activity against human LXRalpha expressed in human HEK293T cells co-expressing CMX-GAL4N-hLXRalpha incubated for 24 hrs by reporter gene assa...More data for this Ligand-Target Pair
Affinity DataEC50: 250nMAssay Description:Agonist activity at LXRalpha (unknown origin) transfected in HEK293T cells incubated for 20 hrs by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 28nMAssay Description:Transactivation of LXRalpha (unknown origin) expressed in CV1 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 60nMpH: 7.5 T: 2°CAssay Description:The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding...More data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Polyhistidine-tagged human LXR ligand-binding domain was mixed with the test compound, biotin-SRC1 peptide, streptavidin-allophycocyanin, and europiu...More data for this Ligand-Target Pair
Affinity DataEC50: 250nMAssay Description:Transactivation of LXRalpha by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 290nMAssay Description:Agonist activity at human LXR-alpha expressed in HEK293 cells after 16 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 135nMAssay Description:Agonist activity at human LXRalpha expressed in Huh7 cells by Gal4 transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at LXRalpha ligand binding domain by FRET based SRC1 recruitment assayMore data for this Ligand-Target Pair
Affinity DataEC50: 55nMpH: 7.5 T: 2°CAssay Description:The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding...More data for this Ligand-Target Pair
Affinity DataEC50: 170nMAssay Description:Agonist activity at human Gal4-LBD fused LXRalpha LBD expressed in Huh7 cells by transient transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 370nMAssay Description:Agonist activity at LXRalpha (unknown origin) expressed in HEK293 cells assessed as transcriptional activity by GAL4 NR reporter cell-based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 490nMAssay Description:Agonist activity at Gal4-tagged LXRalpha (unknown origin) expressed in CHOK1 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Activity against LXR alpha transiently transfected in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 500nMAssay Description:Agonist activity at LXRalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 92nMAssay Description:Binding affinity to human LXRalpha-LBD by surface plasmon resonanceMore data for this Ligand-Target Pair
Affinity DataEC50: 210nMAssay Description:Agonist activity at human LXR-alpha transfected in HEK293 cells after 16 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Agonist activity at human LXRalpha expressed in African green monkey kidney CV1 cells co-expressing pTAL-LXRE including LXR response element incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Displacement of [3H]TO901317 from human recombinant LXRalpha expressed in Escherichia coli by flashplate methodMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Displacement of [3H]T0901317 from LXRalpha ligand binding domainMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Binding affinity at human LXRalphaMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...More data for this Ligand-Target Pair
