Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) for PDB: 1W6J
TargetLanosterol synthase(Human)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50128065({4-[6-(Allyl-methyl-amino)-hexyloxy]-2-fluoro-phen...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imagingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol synthase(Human)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50128065({4-[6-(Allyl-methyl-amino)-hexyloxy]-2-fluoro-phen...)
Affinity DataIC50: 6.5nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol synthase(Human)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50128065({4-[6-(Allyl-methyl-amino)-hexyloxy]-2-fluoro-phen...)
Affinity DataIC50: 6.5nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol synthase(Human)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50128065({4-[6-(Allyl-methyl-amino)-hexyloxy]-2-fluoro-phen...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol synthase(Human)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50128065({4-[6-(Allyl-methyl-amino)-hexyloxy]-2-fluoro-phen...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human C-terminal His6-tagged OSC expressed in Pichia pastoris GS115 using 2,3-oxidosqualene as substrate after 90 mins by 1H NMR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol synthase(Human)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50128065({4-[6-(Allyl-methyl-amino)-hexyloxy]-2-fluoro-phen...)
Affinity DataIC50: 170nMAssay Description:Inhibition of human OSC expressed in Saccharomyces cerevisiae SMY8More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol synthase(Human)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50128065({4-[6-(Allyl-methyl-amino)-hexyloxy]-2-fluoro-phen...)
Affinity DataIC50: 224nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)