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PDB code 2E4Y

Compile Data Set for Download or QSAR

Identical Ligands in BindingDB

Found 3 hits Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 3

  (531/551 = 96%)
(Homo sapiens (Human))
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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410n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3).


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 3

  (549/551 > 99%)
(Rattus norvegicus (Rat))
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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n/an/an/an/a 1.70E+3n/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Effective concentration required for agonistic activity at Metabotropic glutamate receptor 3


Bioorg Med Chem Lett 11: 1919-24 (2001)


Article DOI: 10.1016/s0960-894x(01)00329-8
BindingDB Entry DOI: 10.7270/Q2SQ90XH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 3

  (531/551 = 96%)
(Homo sapiens (Human))
BDBM50052398
PNG
((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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Article
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n/an/an/an/a 3.00E+3n/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing chimeric mGluR3/1a receptor


Bioorg Med Chem Lett 9: 1721-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00266-8
BindingDB Entry DOI: 10.7270/Q2V69K37
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)

Search BindingMOAD for More Affinity Data:

* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
Identities from BLAST output