Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) for PDB: 2NOS
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibitory activity of compound against human inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 4.50E+3nMAssay Description:Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 9.00E+3nMAssay Description:Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 2.66E+4nMAssay Description:Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide product...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 2.85E+4nMAssay Description:Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 5.40E+4nMAssay Description:Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 1.01E+5nMAssay Description:Inhibitory activity against inducible nitric oxide synthase (iNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Rat)
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 1.32E+5nMAssay Description:Inhibition of iNOS-mediated NO production in IL-1beta/IFNgamma-stimulated rat RINmF cells by Griess reactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50207159(hydrazinecarboximidamide | 2-aminoguanidine | 2-az...)
Affinity DataIC50: 1.10E+9nMAssay Description:Inhibitory concentration against nitric oxide synthesis in intact DLD-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)