Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 2W2I
TargetLysine-specific demethylase 4E(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26113(pyridine-2,4-dicarboxylic acid | cid_10365 | pyrid...)
Affinity DataIC50: 300nMAssay Description:Inhibition of his6-tagged human recombinant KDM4E using K9me3 as substrate by SPE-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 4E(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26113(pyridine-2,4-dicarboxylic acid | cid_10365 | pyrid...)
Affinity DataIC50: 1.40E+3nMpH: 7.5 T: 2°CAssay Description:A coupled-assay for JMJD2E activity employing formaldehyde dehydrogenase (FDH) from Pseudomonas putida was developed. Formaldehyde release by demethy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 4E(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26113(pyridine-2,4-dicarboxylic acid | cid_10365 | pyrid...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of KDM4E (unknown origin ) incubated for 20 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 4E(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26113(pyridine-2,4-dicarboxylic acid | cid_10365 | pyrid...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of KDM4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 4E(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26113(pyridine-2,4-dicarboxylic acid | cid_10365 | pyrid...)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of KDM4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 4E(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26113(pyridine-2,4-dicarboxylic acid | cid_10365 | pyrid...)
Affinity DataKi:  9.14E+5nMAssay Description:Inhibition of JMJD2EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)