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Found 5 Enz. Inhib. hit(s) for PDB: 2W3B
TargetDihydrofolate reductase(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50034929(6-[(2,5-Diethoxy-phenylamino)-methyl]-5-methyl-pyr...)
Affinity DataIC50:  0.840nMAssay Description:Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034929(6-[(2,5-Diethoxy-phenylamino)-methyl]-5-methyl-pyr...)
Affinity DataIC50:  17.4nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liverMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034929(6-[(2,5-Diethoxy-phenylamino)-methyl]-5-methyl-pyr...)
Affinity DataIC50:  17.4nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034929(6-[(2,5-Diethoxy-phenylamino)-methyl]-5-methyl-pyr...)
Affinity DataIC50:  370nMAssay Description:Inhibitory activity of the compound against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50034929(6-[(2,5-Diethoxy-phenylamino)-methyl]-5-methyl-pyr...)
Affinity DataIC50:  2.30E+3nMAssay Description:Antimycobacterial activity against human dihydrofolate reductase (hDHFR)More data for this Ligand-Target Pair