Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) for PDB: 2XB7
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  1.10nMAssay Description:Binding constant for ALK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 3nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataEC50:  3nMAssay Description:Inhibition of ALK by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of NPM-fused ALK (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 4nMAssay Description:Inhibition of Tel-fused ALK kinase-mediated mouse BaF3 cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 5.5nMAssay Description:The in-vitro kinase assay was performed using the HTRF kinEASE TK kit available from Cisbio. The operation steps are indicated in the instructions of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 10nMAssay Description:Decrease in ALK phosphorylation in human SUDHL1 cells after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Mouse)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 10nMAssay Description:Decrease in ALK phosphorylation in mouse Ba/F3 NPM-ALK cells after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 10nMAssay Description:Decrease in ALK phosphorylation in human Karpas299 cells after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 16nMAssay Description:Inhibition of EML4/ALK in human NCI-H2228 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 44nMAssay Description:Inhibition of EML4/ALK in human NCI-H3122 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50242742(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Affinity DataIC50: 160nMAssay Description:Inhibition of ALK in human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50242742(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Affinity DataIC50: 296nMAssay Description:Inhibition of ALK in Melphalan Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50242742(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Affinity DataIC50: 458nMAssay Description:Inhibition of ALK in human bortezomib-resistant ANBL6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one sol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50242742(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Affinity DataIC50: 502nMAssay Description:Inhibition of ALK in human ANBL-6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolifera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50242742(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Affinity DataIC50: 604nMAssay Description:Inhibition of ALK in human U-266 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell proliferat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)