Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) for PDB: 3FPD
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300028BDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 27nMAssay Description:Activity at methyl transferase activity GLP by chemiluminescence based oxygen tunneling assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300028BDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 34nMAssay Description:Activity at methyl transferase activity GLP by enzyme coupled S-adenocylehomocystein detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300028BDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 34nMAssay Description:Inhibition of GLP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300028BDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 700nMAssay Description:Inhibition of GLPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300028BDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 700nMAssay Description:Inhibition of human N-terminal hexahistidine-tagged GLP SET domain amino acid 951 to 1235 expressed in Escherichia coli BL21 (DE3) using Histone H3 p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300028BDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 700nMAssay Description:Inhibition of N-terminal hexahistidine-tagged SET domain of human GLP (951 to 1235) expressed in Escherichia coli BL21 (DE3) using Histone H3 peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300028BDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 700nMAssay Description:Inhibition of GLP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300028BDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 700nMAssay Description:Inhibition of EHMT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300028BDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 700nMAssay Description:Inhibition of GST-fused GLP (amino acids 610 to 917) (unknown origin) expressed in Escherichia coli BL21 by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300028BDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 700nMAssay Description:Inhibition of recombinant human GLP (610 to 917 residues) using H3 peptide (1 to 20 residues) by mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300028BDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 700nMAssay Description:Inhibition of GLP (610 to 917 residues ) (unknown origin) expressed in Escherichia coli BL21 using H3(1 to 20)cys as substrate by spectrometry based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300028BDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of GLP (610 to 917 residues ) (unknown origin) expressed in Escherichia coli BL21 using H3(1 to 20)cys as substrate and SAM as cosubstrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300028BDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of Histone H3 lysine 9 of GLP methyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300028BDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of GLP (610 to 917) (unknown origin) assessed as H3K9me2 level by mass spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300028BDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of GLP (unknown origin) using H3(1-20)-cys as substrate by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)