Affinity DataIC50: 5.5nMpH: 7.4 T: 2°CAssay Description:The in vitro inhibitory activity of the compound against Aurora B kinase activity was assayed with reference to a method described in patent publicat...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 10nMAssay Description:Inhibition of SYK in OVA-challenged and IgE-sensitized cells assessed as reduction in IL13 releaseMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Inhibition of SYK in OVA-challenged and IgE-sensitized cells assessed as reduction in TNFalpha releaseMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Inhibition of SYK in OVA-challenged and IgE-sensitized cells assessed as reduction in IL2 releaseMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Inhibition of SYK in OVA-challenged and IgE-sensitized cells assessed as reduction in IL6 releaseMore data for this Ligand-Target Pair
Affinity DataKd: 19nMAssay Description:Binding constant for SYK kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 23.6nMT: 2°CAssay Description:Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...More data for this Ligand-Target Pair
Affinity DataEC50: 33nMAssay Description:Inhibition of SYK in human neutrophils cells assessed as reduction in FcepsilonR1/FcgammaR-mediated signaling responsesMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant SykMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of SYK in human mast cell cultures assessed as reduction in Anti-IgG-stimulated FcgammaR-mediated leukotriene LTC4 production by fluoresce...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Competitive inhibition of SYK (unknown origin) assessed as inhibition constant in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of human SYK assessed as tryptase release measured after 30 mins in presence of ATPMore data for this Ligand-Target Pair
Affinity DataEC50: 48nMAssay Description:Inhibition of SYK in human B-cells cells assessed as reduction in FcepsilonR1/FcgammaR-mediated signaling responsesMore data for this Ligand-Target Pair
Affinity DataEC50: 53nMAssay Description:Inhibition of Syk in antihuman IgM-stimulated human Ramos cells assessed as decrease in BCR-mediated BLNK phosphorylation by cellular assayMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibition of Syk in human RBL-2H3 cells assessed as DNP-BSA-induced beta-hexosaminidase secretion preincubated with compound for 20 mins followed by...More data for this Ligand-Target Pair
Affinity DataEC50: 56nMAssay Description:Inhibition of SYK in cultured human mesangial cells assessed as reduction in FcepsilonR1/FcgammaR-mediated signaling responsesMore data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 68nMAssay Description:Inhibition of Syk (unknown origin) using 4 uM peptide assessed as product formation after 60 mins incubation by microfluidic mobility shift assayMore data for this Ligand-Target Pair
Affinity DataEC50: 111nMAssay Description:Inhibition of SYK in human macrophages assessed as reduction in FcepsilonR1/FcgammaR-mediated signaling responsesMore data for this Ligand-Target Pair
Affinity DataEC50: 151nMAssay Description:Inhibition of Syk in alphaIgM-stimulated human B cells assessed as cell proliferation after 1 hr incubation by flow cytometryMore data for this Ligand-Target Pair
Affinity DataEC50: 171nMAssay Description:Inhibition of SYK in human THP1 cells assessed as reduction in FcepsilonR1/FcgammaR-mediated signaling responsesMore data for this Ligand-Target Pair
Affinity DataEC50: 335nMAssay Description:Inhibition of Syk in alphaIgM-stimulated human B cells assessed as CD86 expression after 1 hr incubation by flow cytometryMore data for this Ligand-Target Pair
Affinity DataIC50: 457nMAssay Description:Inhibition of Syk in anti IgM-stimulated human Ramos cells assessed as BLNK phosphorylation by cellular assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.35E+3nMAssay Description:Inhibition of Syk in human whole blood assessed as inhibition of P-SLP76 in CD14+ monocytes by flow cytometryMore data for this Ligand-Target Pair
Affinity DataEC50: 3.66E+3nMAssay Description:Inhibition of Syk in goat antihuman IgE-induced CD63 expression in human whole blood by FACS analysisMore data for this Ligand-Target Pair
