Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) for PDB: 3HM1
TargetEstrogen receptor(Human)
Marquette University

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataEC50:  2.40nMAssay Description:Agonist activity at full length human ERalpha receptor assessed as transcriptional activity incubated for 22 to 24 hrs by cell based luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Marquette University

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataEC50: >50nMAssay Description:Antagonist activity at full length human ERalpha receptor assessed as inhibition of estradiol-induced activation incubated for 22 to 24 hrs by cell b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Marquette University

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at ER-alpha (unknown origin) by ER-alpha coactivator assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Marquette University

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataEC50:  120nMAssay Description:Ability to activate estrogen receptor 1-mediated transcription.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Marquette University

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataEC50:  7nMAssay Description:Activity at human recombinant ERalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Marquette University

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataIC50: 29nM EC50:  166nMAssay Description:Ligand binding was determined using a scintillation proximity assay with streptavidin-coated SPA beads (Amersham) and biotinylated receptor. Receptor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Marquette University

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataIC50: 96nMAssay Description:Displacement of [3H]17beta-estradiol from human ERalpha expressed in SF9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Marquette University

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataIC50: 210nMAssay Description:Binding affinity towards estrogen receptor alpha by [3H]17-beta-estradiol displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Marquette University

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataIC50: 480nM EC50:  0.700nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)