Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) for PDB: 3K5K
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300041(7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl...)
Affinity DataKd:  23nMAssay Description:Binding affinity to G9a by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300041(7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl...)
Affinity DataKd:  23nMAssay Description:Binding affinity to G9a by isothermal titration colorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300041(7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl...)
Affinity DataIC50: 15nMAssay Description:Inhibition of G9a by Thioglo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300041(7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl...)
Affinity DataIC50: 15nMAssay Description:Inhibition of lysine methyltransferase G9aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300041(7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl...)
Affinity DataIC50: 15nMAssay Description:Inhibition of G9a (unknown origin) using histone H3 (1 to 25 residues) as substrate preincubated for 2 mins followed by substrate addition measured f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300041(7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl...)
Affinity DataIC50: 15nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300041(7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl...)
Affinity DataIC50: 43nMAssay Description:Inhibition of G9a in human MDA-MB-231 cells assessed as reduction of H3K9me2 after 48 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300041(7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl...)
Affinity DataIC50: 60nMAssay Description:Inhibition of N-terminal GST tagged human recombinant EHMT2 (785 to 1210 residues) expressed in baculovirus infected Sf9 insect cells assessed as red...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300041(7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of G9a in human MDA-MB-231 cells assessed as reduction of H3K9me2 after 48 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300041(7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl...)
Affinity DataIC50: 4.30E+4nMAssay Description:Activity at methyl transferase activity G9a by enzyme coupled S-adenocylehomocystein detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300041(7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl...)
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of methyl transferase activity of G9a assessed as inhibition of H3K9 methylation by chemiluminescence based oxygen tunneling assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300041(7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity to human recombinant G9a catalytic domain amino acid 913 to 1193 expressed in Escherichia coli BL21 (DE3) by isothermal titration ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50300041(7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl...)
Affinity DataKi:  2.60nMAssay Description:Inhibition of G9a (unknown origin) using histone H3 (1 to 25 residues) as substrate preincubated for 2 mins followed by substrate addition measured f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)