Compile Data Set for Download or QSAR
maximum 50k data
Found 4 Enz. Inhib. hit(s) for PDB: 3P89
TargetBile acid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50336641(6-[4-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human FXR LBD assessed as SRC1 peptide recruitment by FRET assayMore data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50336641(6-[4-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human FXR LBD transfected in african green monkey CV1 cells after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50336641(6-[4-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human amino-terminal polyhistidine-tagged FXR alpha LBD (amino acids 237 to 472) assessed as cofactor peptide SRC-1 interaction w...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50336641(6-[4-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human FXR LBD iexpressed in monkey CV-1 cells assessed as transactivation of luciferase reporter gene expressionMore data for this Ligand-Target Pair