Affinity DataKd: 0.300nMAssay Description:Binding constant for YES kinase domainMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKd: 0.210nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 0.300nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 0.0700nMAssay Description:Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against a panel...More data for this Ligand-Target Pair
Affinity DataKd: 0.210nMAssay Description:Binding constant for SRC kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.300nMAssay Description:Binding constant for YES kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.210nMAssay Description:Binding constant for SRC kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.210nMAssay Description:Binding affinity to SRC (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Chemical Genomics Centre of The Max Planck Society
Chemical Genomics Centre of The Max Planck Society
Affinity DataIC50: 0.400nM Kd: 11nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Chemical Genomics Centre of The Max Planck Society
Chemical Genomics Centre of The Max Planck Society
Affinity DataIC50: 0.400nM Kd: 11nMAssay Description:Tyrosine kinase inhibition assay using wild type cSrc measured by a fluorescence-labeled approach.More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of C-terminal His-tagged full length human SRC expressed in insect cells preincubated for 20 mins using poly[Glu,Tyr]4:1 as substrate meas...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human YES using poly[Glu,Tyr]4:1 as substrate in presence of [gamma-33P] ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of src kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of yes kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of Yes1 (unknown origin) assessed as kinase-dependent enzymatic production of ADP from ATP using coupled luminescence-based reaction by AD...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human SRC by western blot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of SRC (unknown origin) preincubated for 10 mins followed by substrate addition and measured after 1 hr by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of SRC (unknown origin) preincubated for 10 mins followed by substrate addition and measured after 1 hr by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of c-Src using biotinylated substrate preincubated for 15 mins before substrate addition measured after 30 mins by fluorescence microplate...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:The IC50 for the inhibition of ABL1 by dasatinib, by C7 and by B3 is approximately 1.5 nM, 5.1 nM and 1.6 nM, and of SRC is 1.5 nM, 1.5 nM and 1.5 nM...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Briefly, a radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the five protein kinases. All...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of Src kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of Src kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M](Chicken)
Chemical Genomics Centre of The Max Planck Society
Chemical Genomics Centre of The Max Planck Society
Affinity DataIC50: 480nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
Affinity DataKi: 0.0160nMAssay Description:Binding affinity to Src (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Binding affinity to Src (unknown origin) assessed as inhibition constant in presence of ATP by competitive binding assayMore data for this Ligand-Target Pair
