Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) for PDB: 3QX3
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Umr 176 Cnrs/Institut Curie

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataEC50:  5.60E+4nMAssay Description:Concentration of compound at which inhibitory activity detected against DNA topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Umr 176 Cnrs/Institut Curie

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataEC50:  810nMAssay Description:Compound was tested for topoisomerase II inhibition in purified HeLa cells by SDS/K+ precipitation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article
PDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataEC50: >7.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article
PDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Umr 176 Cnrs/Institut Curie

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataEC50:  810nMAssay Description:Tested for inhibitory activity against Topoisomerase II isolated from HeLa cells by using SDS-K+ precipitation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2018
Entry Details
PDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Umr 176 Cnrs/Institut Curie

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataEC50:  810nMAssay Description:Inhibitory activity in a cell-free assay of DNA cleavage mediated by purified HeLa cell topoisomerase II.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2018
Entry Details
PDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Umr 176 Cnrs/Institut Curie

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataEC50:  810nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details
PDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Umr 176 Cnrs/Institut Curie

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataEC50:  810nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 790nMAssay Description:Inhibition of human topoisomerase-2B after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Umr 176 Cnrs/Institut Curie

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibitory activity in a DNA cleavage assay using HeLa DNA topoisomerase II yielding its effective concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 3.61E+4nMAssay Description:Inhibition of human topoisomerase 2-beta assessed as reduction in relaxation of pBR322 DNA measured after 30 mins by agarose gel electrophoresis meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 3.76E+4nMAssay Description:Inhibition of human DNA topoisomerase 2 beta assessed as relaxation of supercoiled plasmid pBR322 DNA incubated for 30 mins by ethidium bromide stain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Umr 176 Cnrs/Institut Curie

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 3.80E+4nMAssay Description:In vitro activity against mammalian topoisomerase II measured as ATP-dependent unknotting of P4 DNA compared to enzyme and DNA controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Umr 176 Cnrs/Institut Curie

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 5.04E+4nMAssay Description:Inhibitory concentration against human DNA topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)