Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 4AN2
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 0.900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 4.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)