Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) for PDB: 4EA3
TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181392(1-benzyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperid...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181392(1-benzyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperid...)
Affinity DataIC50: 0.150nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTP-gamma-S binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181392(1-benzyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperid...)
Affinity DataIC50: 0.270nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181392(1-benzyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperid...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]N/OFQ from human recombinant NOP receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)