Compile Data Set for Download or QSAR
maximum 50k data
Found 4 Enz. Inhib. hit(s) for PDB: 4EA3
TargetNociceptin receptor(Homo sapiens (Human))
University Of Ferrara

Curated by ChEMBL
LigandPNGBDBM50181392((R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]N/OFQ from human recombinant NOP receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
University Of Ferrara

Curated by ChEMBL
LigandPNGBDBM50181392((R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-...)
Affinity DataIC50:  0.150nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
University Of Ferrara

Curated by ChEMBL
LigandPNGBDBM50181392((R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-...)
Affinity DataIC50:  0.270nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
University Of Ferrara

Curated by ChEMBL
LigandPNGBDBM50181392((R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair