Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 4EZ7
TargetCyclin-dependent kinase 2(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM60927(ANS | BDBM50126831 | 1-anilinonaphthalene-8-sulfon...)
Affinity DataKd:  3.70E+4nMAssay Description:Binding affinity to CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 2(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM60927(ANS | BDBM50126831 | 1-anilinonaphthalene-8-sulfon...)
Affinity DataKd:  3.70E+4nMAssay Description:Binding affinity to human CDK2 (1 to 298 residues) expressed in Escherichia coli Tuner(DE3) assessed as dissociation constant by fluorescence spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 2(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM60927(ANS | BDBM50126831 | 1-anilinonaphthalene-8-sulfon...)
Affinity DataKd:  3.70E+4nMAssay Description:Binding affinity to human Cdk2 by fluorescence spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Gi Therapeutics

US Patent
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 3.93nMAssay Description:For the measurement of CDK2/cyclinE activity, enzyme (0.22 nM) was incubated with 100 mM ATP and the phosphoacceptor substrate peptide (1 mM) for one...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM60927(ANS | BDBM50126831 | 1-anilinonaphthalene-8-sulfon...)
Affinity DataIC50: 9.10E+4nMAssay Description:Inhibition of CDK2/Cyclin A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM60927(ANS | BDBM50126831 | 1-anilinonaphthalene-8-sulfon...)
Affinity DataIC50: 9.10E+4nMAssay Description:Inhibition of CDK2/cyclinA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)