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Compound Name:

Compounds Sorted by Binding Data per Compound

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55
56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81
82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105
106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124
125 127 128 129 130 132 133 134 135 136 137 138 139 140 141 143 144 145 146
147 148 149 150 151 153 154 155 156 159 160 161 163 164 165 168 170 171 173
174 176 178 179 183 184 186 188 189 190 191 192 193 196 198 199 200 203 204
205 206 207 208 209 210 216 220 224 226 227 229 232 237 238 241 243 248 252
253 259 261 270 274 276 277 285 291 303 304 313 318 323 325 328 333 335 337
339 341 353 360 361 365 389 393 398 401 413 433 442 444 445 446 447 448 451
453 454 455 457 458 460 463 465 467 473 477 478 482 484 499 504 505 506 517
521 525 543 549 551 554 591 606 663 691 708 796 804 821 825 833 842 847 854
855 861 873 879 883 887 913 914 925 926 938 947 1010 1027 1050 1052 1081 1082
1099 1115 1130 1133 1206 1262 1543 1639 1903 2029
Compounds Sorted Alphabetically
Compound Name (alphabetical)
Enz. Inhib. Data
ITC Data
Binding Targets
Alternate Compound Names
1 Ki 20 IC50
  • Cytoplasmic tyrosine-protein kinase BMX
  • EGF-R Tyrosine Kinase Mutant (T790M)
  • JAK3
  • Nuclear receptor subfamily 2 group C member 2 (TAK1)
  • Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase Blk
  • Tyrosine-protein kinase ITK/TSK
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase TEC
  • BMX-IN-1
  • N-[5-[9-[4-(methanesulfonamido)phenyl]-2-oxobenzo[h][1,
  • US10000483, Compound I-14
2 Ki 19 IC50
  • Acetylcholinesterase
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • Butyrylcholinesterase (BChE)
  • Cholinesterase
  • Monoamine Oxidase Type B (MAO-B)
  • Monoamine oxidase
  • (3R)-3-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-5-yl N-ethyl-N-methylcarbamate hydrochloride
  • Aminoindan deriv. (R)18b
  • Aminoindan deriv. (R)18b.HCl
  • N-propargylaminoindan (R)18b.HCl
  • R-CPAI
1 Ki 17 IC50 3 EC50
  • Egl nine homolog 1
  • Hypoxia-inducible factor 1 (FIH)
  • Prolyl 3-hydroxylase OGFOD1
  • Prolyl 4-hydroxylase
  • Prolyl hydroxylase EGLN3
  • Vascular endothelial growth factor A
  • US8598210, 119
  • US8598210, Table XV, 10
  • US8598210, Table XV, 11
  • US8722895, 10: {[5-(3-Chlorophenyl)-3-hydroxypyridine-2- carbonyl]amino}-acetic acid trifluoroacetic acid salt
  • US8722895, 11: {[5-(3-Chlorophenyl)-3-hydroxypyridine-2- carbonyl]amino}-acetic acid
  • US9598370, Example 00136
  • USRE47437, Example {[5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acid
21 Ki
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
  • US8598206, 117
  • US8598206, 123
21 Ki
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
  • US8598206, 118
  • US8598206, 122
1 Ki 20 IC50
  • Cytochrome P450 1A
  • Cytochrome P450 2A6
  • Cytochrome P450 2B6
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 2E1
  • Cytochrome P450 3A
  • Dipeptidyl peptidase 4
  • (1S,3S,5S)-2-[(2S)-2-amino-2-(3,5-dihydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; 2,2,2-trifluoroacetic acid
  • (S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methanoprolinenitrile TFA salt
  • BMS-477118
  • Saxagliptin analogue 28
3 Ki 18 IC50
  • Dipeptidyl peptidase 2 (DPP II)
  • Dipeptidyl peptidase 4
  • Dipeptidyl peptidase IV
  • Dipeptidyl peptidase VIII
  • (2S)-1-[(2S)-2-amino-2-cyclohexylacetyl]pyrrolidine-2-carbonitrile
  • BMCL15687 Compound 3
  • CHEMBL307636
  • Cyclohexylglycine-(2S)-cyanopyrolidine 3
  • Cyclohexylglycine-(2S)-cyanopyrrolidine 2
21 Kd
  • ABL Mutant (T315I)
  • Angiopoietin-1 receptor
  • Cyclin-dependent kinase 2
  • Cyclin-dependent kinase 3 (CDK3)
  • Cyclin-dependent kinase 7
  • Cyclin-dependent-like kinase 5
  • Epithelial discoidin domain-containing receptor 1
  • Homeodomain-interacting protein kinase 1
  • Mast/stem cell growth factor receptor Kit
  • Mitogen-activated protein kinase 12
  • PITSLRE serine/threonine-protein kinase CDC2L1
  • Platelet-derived growth factor receptor (PDGFr)
  • Platelet-derived growth factor receptor alpha
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Serine/threonine-protein kinase 10
  • Serine/threonine-protein kinase B-raf
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase receptor FLT3
  • Vascular endothelial growth factor receptor 1
  • Vascular endothelial growth factor receptor 2
  • Vascular endothelial growth factor receptor 3
  • US8765747, 2
21 IC50
  • HIV-1 Reverse Transcriptase
  • HIV-1 Reverse Transcriptase Mutant (K103N)
  • HIV-1 Reverse Transcriptase Mutant (L100I)
  • HIV-1 Reverse Transcriptase Mutant (P236L)
  • HIV-1 Reverse Transcriptase Mutant (Y181C)
  • Human immunodeficiency virus type 1 reverse transcriptase
  • 3-[[(4,7-Dichlorobenzoxazol-2-yl)-methyl]amino]-5-ethyl-6-methylpyridin-2(1H)-one
  • 3-{[(4,7-dichloro-1,3-benzoxazol-2-yl)methyl]amino}-5-ethyl-6-methyl-1,2-dihydropyridin-2-one
  • CHEMBL268871
  • L-697,661
  • Pyridinone deriv.
21 IC50
  • Cytochrome P450 2C9
  • Cytochrome P450 3A
  • Glycogen synthase kinase-3
  • Mitogen-activated protein kinase 12
  • Mitogen-activated protein kinase 14
  • Potassium voltage-gated channel subfamily H member 2
  • Proto-oncogene tyrosine-protein kinase Src
  • Tyrosine-protein kinase SYK
  • US10435361, Example 16
  • US8927563, I
  • US9481648, 16
  • US9790174, Example 16
21 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 15
  • US8969352, 15
  • US9611277, Example 15
  • US9845333, 15
21 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 19
  • US8969352, 19
  • US9611277, Example 19
  • US9845333, 19
21 IC50
  • Cereblon/Histone deacetylase 1
  • Cereblon/Histone deacetylase 2
  • Cereblon/Histone deacetylase 6
  • HDAC1/NCOR2
  • HDAC2/NCOR2
  • HDAC3/NCOR2
  • Histone deacetylase 1
  • Histone deacetylase 10
  • Histone deacetylase 11
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
  • UF010
  • US10807944, Compound UF010
21 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • US9062078, 164
  • US9062078, 83
  • US9475819, 83
  • US9637496, 164
  • US9695183, 164
21 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • US9062078, 192
  • US9062078, 279
  • US9475819, 192
  • US9637496, 279
  • US9695183, 279
10 Ki 11 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • US10323032, Example 7
  • US9096596, 7
  • US9604982, Example 7
10 Ki 11 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • US10323032, Example 12
  • US9096596, 12
  • US9604982, Example 12
5 Ki 15 IC50 1 Kd
  • Histone-arginine methyltransferase CARM1
  • Protein arginine N-methyltransferase 3
  • Protein arginine N-methyltransferase 6
  • Protein arginine N-methyltransferase 8
  • Protein arginine methyltransferase 3 (PRMT3)
  • Protein arginine methyltransferase 8 (PRMT8)
  • Protein-arginine N-methyltransferase 1
  • MS023 (Compound 3)
  • N1-((4-(4-isopropoxyphenyl)-1H-pyrrol-3-yl)methyl)-N1-methylethane-1,2-diamine
11 Ki 10 IC50
  • Beta-hexosaminidase subunit alpha (HexA)
  • Beta-hexosaminidase subunit beta (Hex B)
  • Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS)
  • Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) Mutant KICB1
  • Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) Mutant SP21
  • Dihydrofolate reductase
  • 6-ethyl-5-phenylpyrimidine-2,4-diamine
  • CHEMBL22148
  • P20
19 Ki 2 IC50
  • Nitric Oxide Synthase, brain Mutant (D597N)
  • Nitric Oxide Synthase, endothelial
  • Nitric Oxide Synthase, inducible
  • Nitric oxide synthase mutant (nNOS M336V/D597N)
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Nitric oxide synthase, inducible
  • Nitric-oxide synthase, brain
  • Nitric-oxide synthase, endothelial
  • US10759791, Compound 14j
  • nNOS inhibitor, 5
21 IC50
  • 72 kDa type IV collagenase
  • A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)
  • A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)
  • Collagenase 3
  • Matrix metalloproteinase 12
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-14 (MMP14)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)
  • Metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)
  • Neutrophil collagenase
  • Stromelysin-1
  • US9206139, 1
8 IC50 13 EC50
  • CD63 antigen
  • E3 ubiquitin-protein ligase XIAP/JAK2
  • Tyrosine-protein kinase SYK
  • 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
  • US10342794, Example Ex.-2
  • US10828299, Example Ex.-2
  • US9290505, Ex.-2
  • US9504684, Ex.-2
  • US9931338, Ex.-2
21 Ki
  • CNR1
  • Cannabinoid receptor 1
  • Cannabinoid receptor 2
  • 2-[(1S,2S,5S)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol
  • 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol
  • CP 55,940
  • CP-55,940
  • CP-56667 [(+)-AC],XV
  • [3H]-56
  • [3H]CP55940
21 IC50
  • Sodium channel alpha subunit
  • Sodium channel protein type 2 alpha subunit
  • Sodium channel protein type 5 subunit alpha
  • Sodium channel protein type 7 subunit alpha
  • Sodium channel protein type 8 subunit alpha
  • Sodium channel protein type 9 subunit alpha
  • Voltage-gated sodium channel
  • US9212182, 477
  • US9212182, 478
21 IC50
  • 1,3-beta-glucan synthase component GLS2
  • Baculoviral IAP repeat-containing protein 2/Estrogen receptor
  • Estrogen receptor
  • Estrogen-Related Receptor, gamma
  • Estrogen-related receptor alpha
  • Estrogen-related receptor beta
  • Estrogen-related receptor gamma
  • Steroid hormone receptor ERR2
  • von Hippel-Lindau disease tumor suppressor/Steroid hormone receptor ERR1
  • 4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hydroxy-2-phenylpent-1-en-1-yl]phenol
  • 4-hydroxytamoxifen (4-OHT) analog, 15
  • GSK 5182
19 Ki 2 EC50
  • HRH3
  • Histamine H3 receptor
  • Histamine H4 receptor
  • Histamine receptor (H3 and H4)
  • N(alpha)-Methylhistamine
  • N-alpha-methylhistamine
  • N-methylhistamine
  • NAMH
  • [2-(1H-imidazol-5-yl)ethyl](methyl)amine
  • [3H]N-alpha-methyl histamine
21 IC50
  • Cyclooxygenase
  • Cyclooxygenase-2 (COX-2)
  • Prostaglandin G/H synthase (cyclooxygenase)
  • 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}-N-[(2R)-1-hydroxypropan-2-yl]acetamide
  • CHEMBL24874
  • alpha-substituted indomethacin ethanolamide, 6
21 IC50
  • Cyclooxygenase
  • Cyclooxygenase-2 (COX-2)
  • Prostaglandin G/H synthase (cyclooxygenase)
  • 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}-N-[(2S)-1-hydroxypropan-2-yl]acetamide
  • CHEMBL281847
  • alpha-substituted indomethacin ethanolamide, 7
21 IC50
  • 1,3-beta-glucan synthase component GLS2
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • DNA-dependent protein kinase
  • Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  • Serine-protein kinase ATM
  • Serine/threonine-protein kinase ATR
  • mTOR/FKBP12A/FKBP12B
  • US9428503, 1
21 IC50
  • Coagulation factor XI
  • Plasma kallikrein
  • US10183932, Example 140
  • US9434690, 140
  • US9434690, 66
  • US9434690, 67
  • US9434690, 68
  • US9822102, Example 140
21 IC50
  • Coagulation factor XI
  • Plasma kallikrein
  • US10183932, Example 93
  • US9434690, 90
  • US9434690, 91
  • US9434690, 92
  • US9434690, 93
  • US9822102, Example 93
21 IC50
  • Coagulation factor XI
  • Plasma kallikrein
  • US10183932, Example 135
  • US9434690, 132
  • US9434690, 133
  • US9434690, 134
  • US9434690, 135
  • US9822102, Example 135
21 IC50
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase Mer
  • Tyrosine-protein kinase receptor TYRO3
  • Tyrosine-protein kinase receptor UFO
  • US10053465, 11
  • US10065963, Compound 11
  • US10125150, Example 11
  • US10336759, # 11
  • US10479803, Example 11
  • US10519163, Example 11
  • US10675284, Example 11
  • US9732097, Example 11
  • {trans-3-(4-{[4-[(3- hydroxyazetidin-1- yl)methyl]-6- (trifluoromethyl) pyridin-2- yl]oxy}piperidin-1- yl)-1-[4-(7H- pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]cydobutyl} acetonitrile
21 IC50
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase Mer
  • Tyrosine-protein kinase receptor TYRO3
  • Tyrosine-protein kinase receptor UFO
  • US10053465, 12
  • US10065963, Compound 12
  • US10125150, Example 12
  • US10336759, # 12
  • US10479803, Example 12
  • US10519163, Example 12
  • US10675284, Example 12
  • US9732097, Example 12
  • {trans-3-(4-{[4- {[(2S)-2- (hydroxymethyl) pyrrolidin-1-yl] methyl}-6- (trifluoromethyl) pyridin-2- yl]oxy}piperidin-1- yl)-1-[4-(7H- pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]cyclobutyl} acetonitrile
7 Ki 14 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • US10112937, Example 102
  • US10150765, Example 102
  • US10703749, Example 331
  • US9464084, 101
  • US9464084, 102
6 Ki 15 IC50
  • 1,3-beta-glucan synthase component GLS2
  • Cytochrome P450 2C19
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • US10112937, Example 193
  • US10150765, Example 193
  • US10703749, Example 193
  • US9464084, 193
21 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine-specific histone demethylase 1A (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10053456, 28
  • US10414761, Example 28
  • US9487511, 28
  • US9718814, 28
  • US9920047, 28
21 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine-specific histone demethylase 1A (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10053456, 72
  • US10414761, Example 72
  • US9487511, 72
  • US9718814, 72
  • US9920047, 72
6 Ki 5 IC50 9 Kd 1 EC50
  • ADRB2
  • Beta-1 adrenergic receptor
  • Beta-2 adrenergic receptor
  • Beta-3 adrenergic receptor
  • Beta-adrenergic receptor kinase 1
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Multidrug resistance-associated protein 4
  • 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol
  • 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol, 5
  • Brethaire
  • Brethine
  • Bricanyl
  • Terbutaline
  • Terbutaline,(+/-)
16 Ki 5 IC50
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Carbonic Anhydrase III
  • Carbonic Anhydrase VA
  • Carbonic Anhydrase VB
  • Carbonic Anhydrase XIII
  • Carbonic Anhydrase XIV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • Carbonic anhydrase 6 (CA-VI)
  • Carbonic anhydrase 7
  • Carbonic anhydrase 9
  • Multidrug resistance-associated protein 4
  • 2-chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide
  • Chlortalidone
  • Chlorthalidone
  • Chlorthalidone (1)
  • Hygroton
  • Phthalamudine
  • US10172837, Chlorthalidone
9 Ki 12 IC50
  • Coagulation factor X
  • Coagulation factor XI
  • Plasminogen
  • Prothrombin
  • Tissue-type plasminogen activator
  • Trypsin
  • Urokinase-type plasminogen activator/surface receptor
  • Vitamin K-dependent protein C
  • Exanta
  • Melagatran
12 Ki 9 IC50
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Disintegrin and metalloproteinase domain-containing protein 17
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
  • Cipemastat
  • Trocade
21 IC50
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • RET Kinase (V804M) (aa658-end)
  • RET Kinase (aa 658-1114)
  • RET kinase mutant (G810R)
  • RET kinase mutant (V804M)
  • BDBM305696
  • US10144734, Example 713
  • US10172845, Example 714
  • US10441581, Example 714
  • US10881652, Example 714
1 Ki 18 IC50 2 EC50
  • 1,3-beta-glucan synthase component GLS2
  • 5-hydroxytryptamine receptor 1A
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • Dihydrofolate reductase
  • Multidrug resistance-associated protein 4
  • Pteridine reductase 1
  • Sodium channel protein type 2 alpha subunit
  • Sodium channel protein type II alpha subunit
  • Twik-RElated Potassium (K+) channel 1 (TREK1)
  • Uridine-5'-diphosphoglucuronosyltransferase 1A1
  • CHEMBL744
  • MLS000069369
  • RILUZOLE
  • SMR000058231
  • cid_5070
17 IC50 4 EC50
  • DNA (cytosine-5)-methyltransferase 1 (DNMT1)
  • Eph receptor A4
  • Estradiol receptor beta (ERβ)
  • Focal adhesion kinase 1
  • G-protein subunit alpha-16
  • Heat Shock 70kDa Protein 1
  • Hematopoietic protein-tyrosine phosphatase (HEPTP)
  • MKP-3
  • POsterior Segregation family member (pos-1)
  • PTK2B protein tyrosine kinase 2 beta (PTK2B)
  • RecName: Full=Zinc finger protein mex-5
  • dTDP-4-dehydrorhamnose 3,5-epimerase RmlC
  • heat shock 70kDa protein 8 isoform 1
  • mothers against decapentaplegic homolog 3
  • nuclear receptor subfamily 4, group A, member 1
  • trace amine-associated receptor 1
  • 3-bromanyl-5-(3,3-dimethylpiperidin-1-yl)carbonyl-pyran-2-one
  • 3-bromo-5-(3,3-dimethylpiperidine-1-carbonyl)pyran-2-one
  • 3-bromo-5-[(3,3-dimethyl-1-piperidinyl)-oxomethyl]-2-pyranone
  • MLS000080954
  • SMR000044848
  • cid_664033
21 IC50
  • Dual Specificity Protein Phosphatase 1
  • Dual specificity phosphatase Cdc25B
  • Glucose 6-phosphate dehydrogenase (G6PD)
  • MKP-3
  • glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
  • MLS000096457
  • N-phenyl-1-(4-pyridyl)methanimine oxide
  • N-phenyl-1-pyridin-4-yl-methanimine oxide
  • N-phenyl-1-pyridin-4-ylmethanimine oxide
  • SMR000062185
  • cid_768563
15 Ki 6 IC50
  • AVPR1A
  • Oxytocin receptor
  • Vasopressin V1a receptor
  • Vasopressin V1b receptor
  • Vasopressin V2 Receptor
  • Vasopressin V2 receptor
  • Vasopressin receptor
  • CHEMBL420762
  • Mozavaptan
  • N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-2-methyl-benzamide
  • OPC-31260
16 IC50 5 EC50
  • 1,3-beta-glucan synthase component GLS2
  • Cytochrome P450
  • Cytochrome P450 4B1
  • PIK3CG/PIK3R1
  • Phosphatidylinositol 3-kinase regulatory subunit beta
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  • Phosphoinositide 3-Kinase (PI3K), delta
  • p110α/p85α
  • p110β/p85α
  • US10227350, Compound 113
  • US10227350, Compound 114
  • US10227350, Compound 44
21 IC50
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  • US10428087, Example 44
  • US10829502, Example 44
  • US9975907, Example 12
  • US9975907, Example 44
21 IC50
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  • US10428087, Example 23
  • US10829502, Example 23
  • US9975907, Example 13
  • US9975907, Example 23
3 Ki 8 IC50 10 EC50
  • Alkaline phosphatase placental-like
  • Alkaline phosphatase, tissue-nonspecific isozyme
  • Alpi
  • G protein signalling regulator 19
  • Intestinal alkaline phosphatase
  • M18 aspartyl aminopeptidase
  • Procathepsin L
  • RGS7
  • Regulator of G-protein signaling 8
  • nuclear receptor subfamily 4, group A, member 1
  • protein artemis isoform a
  • regulator of G-protein signaling 4
  • regulator of G-protein signalling 16
  • 2-[2-oxidanylidene-2-[2-[(Z)-(3-oxidanyl-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)methyl]hydrazinyl]ethoxy]-N''-[(Z)-(3-oxidanyl-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)methyl]benzohydrazide
  • MLS000540767
  • N'-(3,4-dihydroxybenzylidene)-2-{2-[2-(3,4-dihydroxybenzylidene)hydrazino]-2-oxoethoxy}benzohydrazide
  • N''-[(Z)-(3-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]-2-[2-[N''-[(E)-(3-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]hydrazino]-2-keto-ethoxy]benzohydrazide
  • N''-[(Z)-(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-2-[2-[[(Z)-(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]hydrazo]-2-oxoethoxy]benzohydrazide
  • N''-[(Z)-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-[2-[2-[(Z)-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]hydrazinyl]-2-oxoethoxy]benzohydrazide
  • N'-[(Z)-(3-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]-2-[2-[N'-[(E)-(3-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]hydrazino]-2-keto-ethoxy]benzohydrazide
  • N'-[(Z)-(3-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]-2-[2-[N'-[(Z)-(3-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]hydrazino]-2-keto-ethoxy]benzohydrazide
  • SMR000161891
  • cid_11958779
19 IC50 2 EC50
  • Apoptotic peptidase activating factor 1
  • Beta-galactosidase
  • C-C chemokine receptor type 6 (CCR6)
  • Caspase-3
  • Caspase-9
  • DNA damage-inducible transcript 3 protein
  • Glucose 6-phosphate dehydrogenase (G6PD)
  • SUMO-1-specific protease
  • SUMO/sentrin specific peptidase family member 8
  • Serine/threonine-protein kinase PLK1
  • XBP1
  • glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
  • neutrophil cytosolic factor 1
  • putative hexokinase HKDC1
  • 2-[[(4E)-1-keto-4-(2-thienylsulfonylimino)-2-naphthyl]amino]benzoic acid methyl ester
  • 2-[[(4E)-1-oxo-4-thiophen-2-ylsulfonylimino-2-naphthalenyl]amino]benzoic acid methyl ester
  • MLS000521465
  • SMR000131873
  • cid_9550941
  • methyl 2-[[(4E)-1-oxidanylidene-4-thiophen-2-ylsulfonylimino-naphthalen-2-yl]amino]benzoate
  • methyl 2-[[(4E)-1-oxo-4-thiophen-2-ylsulfonyliminonaphthalen-2-yl]amino]benzoate
21 IC50
  • Toll-like receptor 7
  • Toll-like receptor 8
  • Toll-like receptor 9
  • US10544143, Example 400
  • US10544143, Example 420
  • US10544143, Example 422
  • US10730877, Example 422
21 IC50
  • Ataxin-1
  • 1-((3aR,8aS)-2-(1H-Benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(3-fluoro-4-(trifluoromethoxy)phenyl)propan-1-one
  • US10669268, Example 17
  • US10669268, Example 17.01
  • US10669268, Example 17.02
  • US10669268, Example 17.03
  • US10669268, Example 17.04
  • US10669268, Example 17.05
  • US10669268, Example 17.06
  • US10669268, Example 17.07
  • US10669268, Example 17.08
  • US10669268, Example 17.09
  • US10669268, Example 17.10
  • US10669268, Example 17.11
  • US10669268, Example 17.12
  • US10669268, Example 17.13
  • US10669268, Example 17.14
  • US10669268, Example 17.15
  • US10669268, Example 17.16
  • US10669268, Example 17.17
  • US10669268, Example 17.18
  • US10669268, Example 17.19
  • US10669268, Example 17.20
19 IC50 2 EC50
  • 26S Proteasome regulatory subunit Rpn11 (Rpn11)
  • Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
  • Hematopoietic protein-tyrosine phosphatase (HEPTP)
  • POsterior Segregation family member (pos-1)
  • RecName: Full=Zinc finger protein mex-5
  • Thrombin
  • envelope glycoprotein
  • tyrosine-protein phosphatase non-receptor type 12 isoform 2
  • 4-[(5Z)-5-[[5-(1,3-benzothiazol-2-yl)-2-furanyl]methylidene]-4-oxo-2-sulfanylidene-3-thiazolidinyl]butanoic acid
  • 4-[(5Z)-5-[[5-(1,3-benzothiazol-2-yl)-2-furyl]methylene]-4-keto-2-thioxo-thiazolidin-3-yl]butyric acid
  • 4-[(5Z)-5-[[5-(1,3-benzothiazol-2-yl)furan-2-yl]methylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid
  • 4-[(5Z)-5-[[5-(1,3-benzothiazol-2-yl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid
  • MLS-0109411.0001
  • cid_2012947
4 Ki 5 IC50 12 EC50
  • DNA dC->dU-editing enzyme APOBEC-3G
  • G protein signalling regulator 19
  • Oxytocin receptor
  • RGS7
  • Regulator of G-protein signaling 8
  • Vasopressin V1a receptor
  • Voltage-gated calcium channel subunit alpha Cav2.2
  • eukaryotic translation initiation factor 4 gamma, 1 isoform 4
  • neuronal munc18-1 binding protein
  • probable DNA dC->dU-editing enzyme APOBEC-3A
  • regulator of G-protein signaling 4
  • regulator of G-protein signalling 16
  • (4-chlorodithiazol-5-ylidene)-(4-chloro-2-methyl-phenyl)amine
  • 4-chloranyl-N-(4-chloranyl-2-methyl-phenyl)-1,2,3-dithiazol-5-imine
  • 4-chloro-N-(4-chloro-2-methylphenyl)-5-dithiazolimine
  • 4-chloro-N-(4-chloro-2-methylphenyl)dithiazol-5-imine
  • 4-chloro-N-(4-chloro-5H-1,2,3-dithiazol-5-yliden)-2-methylaniline
  • MLS000539990
  • SMR000125448
  • cid_1471255
21 IC50
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor
  • Fibroblast growth factor receptor 1
  • Insulin-like growth factor I receptor
  • Platelet-derived growth factor receptor beta
  • Proto-oncogene tyrosine-protein kinase Src
  • Receptor tyrosine-protein kinase erbB-2
  • Vascular endothelial growth factor receptor 1
  • Vascular endothelial growth factor receptor 2
  • (Z)-3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-yl)methylidenyl]indolin-2-one
  • 3-(4-methyl-2-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid
  • CHEMBL89363
  • KDR Kinase Inhibitor, 5
  • SU5402
21 Ki
  • Cannabinoid receptor 1
  • Cannabinoid receptor 2
  • Sigma non-opioid intracellular receptor 1
  • (+)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol
  • (R)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol
  • 6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol
  • CHEMBL10883
  • THC, delta 9
  • Tetrahydrocannabinol
21 Ki
  • Delta-type opioid receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • OPRD1
  • Sigma non-opioid intracellular receptor 1
  • (2S,6S,11S)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol
  • (SSS)-12-Cyclopropylmethyl-13-methyl-12-aza-tricyclo[9.1.1.0*3,8*]trideca-3(8),4,6-trien-6-ol(cyclazocine)
  • 3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol
  • CHEMBL293349
  • CYCLAZOCINE (-)
  • Cyclazocine
  • Cyclazocine (+)
19 Ki 2 IC50
  • 5-hydroxytryptamine receptor 1A
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • Beta-1 adrenergic receptor
  • Beta-2 adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • Serotonin (5-HT) receptor
  • Serotonin 1 (5-HT1) receptor
  • Serotonin 1B/1D receptor
  • Serotonin 2 (5-HT2) receptor
  • Serotonin 3a (5-HT3a)/3b (5-HT3b)/3c (5-HT3c)/3d (5-HT3d)/3e (5-HT3e) receptor
  • Sigma non-opioid intracellular receptor 1
  • 1-Phenyl-piperazine
  • CHEMBL9434
  • PHENYLPIPERAZINE
17 Ki 3 Kd 1 EC50
  • Muscarinic acetylcholine receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M3
  • CHEMBL310852
  • N-Methyl-N-(1-methyl-4-pyrrolidin-1-yl-but-2-ynyl)-acetamide
  • N-Methyl-N-(1-methyl-4-pyrrolidin-1-yl-but-2-ynyl)-acetamide (BM 5)
  • N-Methyl-N-(1-methyl-4-pyrrolidin-1-yl-but-2-ynyl)-acetamide (R)
  • N-Methyl-N-(1-methyl-4-pyrrolidin-1-yl-but-2-ynyl)-acetamide (S)
21 IC50
  • Acyl coenzyme A:cholesterol acyltransferase 1
  • Acyl-CoA:cholesterol acyltransferase
  • Sterol O-acyltransferase 1
  • Sterol O-acyltransferase, Soat
  • 2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phenyl)-amide
  • CHEMBL22373
  • CI-976
13 Ki 8 IC50
  • 5-hydroxytryptamine receptor 2A
  • Alpha-1A adrenergic receptor
  • Beta-2 adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • Histamine H1 receptor
  • Muscarinic acetylcholine receptor M2
  • adrenergic Alpha2
  • 3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide
  • 3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide
  • A 35043
  • CHEMBL283099
20 Ki 1 IC50
  • ALK tyrosine kinase receptor
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 3
  • Focal adhesion kinase 1
  • Macrophage colony-stimulating factor 1 receptor (CSF1R)
  • Mast/stem cell growth factor receptor Kit
  • PTK2B protein tyrosine kinase 2 beta (PTK2B)
  • Phosphorylase kinase
  • Platelet-derived growth factor receptor beta
  • Potassium voltage-gated channel subfamily H member 2
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Serine/threonine-protein kinase Chk1/2
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase ABL2
  • Tyrosine-protein kinase Fyn
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase receptor FLT3
  • Tyrosine-protein kinase receptor UFO
  • Vascular endothelial growth factor receptor 1
  • Vascular endothelial growth factor receptor 2
  • Vascular endothelial growth factor receptor 3
  • CHEMBL3288854
21 IC50
  • Betaine transporter
  • GABA transporter
  • GABA transporter 1
  • GABA transporter 3
  • Sodium- and chloride-dependent GABA transporter 1
  • (S)-Piperidine-3-carboxylic acid
  • (S)-nipecotic acid
  • CHEMBL77484
14 Ki 7 IC50
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Carbonic Anhydrase VA
  • Carbonic Anhydrase VB
  • Carbonic Anhydrase XIII
  • Carbonic Anhydrase XIV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • Carbonic anhydrase 6 (CA-VI)
  • Carbonic anhydrase 7
  • Carbonic anhydrase 9
  • Human herpesvirus 1 DNA polymerase
  • Human immunodeficiency virus type 1 reverse transcriptase
  • Multidrug resistance-associated protein 4
  • (phosphonoformate)Trisodium phosphonoformate
  • Antiviral agent : Inhibitor of reverse transcriptase of Human T-cell lymphotropic, virus type III, useful in the treatment of HSV-1 infections
  • CHEMBL754
  • EHB-776
  • FOSCARNET SODIUM
  • Foscarnet
  • Foscavir
  • phosphonoformate trisodium salt
  • trisodium dioxidophosphinecarboxylate oxide
  • trisodium dioxidophosphinecarboxylate oxide with 6 molecules of water(foscarnet)
  • trisodium phosphonoformate
9 IC50 12 EC50
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2B
  • Alpha-1A adrenergic receptor
  • Alpha-2A adrenergic receptor
  • Apelin receptor
  • Beta-2 adrenergic receptor
  • Cannabinoid receptor 1
  • D(1A) dopamine receptor
  • Muscarinic acetylcholine receptor M2
  • Prostanoid TP receptor
  • CHEMBL3338677
16 Ki 5 IC50
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • Bile salt export pump
  • D(2) dopamine receptor
  • HTR1D
  • HTR2C
  • Norepinephrine Monoamine transporters
  • Norepinephrine transporter
  • Serotonin (5-HT) receptor
  • Serotonin 1B/1D receptor
  • Sodium-dependent dopamine transporter
  • Sodium-dependent serotonin transporter
  • 3-(2-Piperidin-4-yl-ethyl)-1H-indole
  • CHEMBL276520
  • Indalpine
21 IC50
  • 5-Lipoxygenase/5-lipoxygenase activating protein
  • 5-lipoxygenase/FLAP
  • Arachidonate 5-lipoxygenase
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • 2-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl]-2-methyl-propionic acid
  • 3-(1-(4-chlorobenzyl)-3-(tert-butylthio)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid
  • 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid
  • 3-[3-(TERT-BUTYLTHIO)-1-(4-CHLOROBENZYL)-5-(QUINOLIN-2-YLMETHOXY)-1H-INDOL-2-YL]-2,2-DIMETHYLPROPANOIC ACID
  • 3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid
  • CHEMBL16596
  • L-686708
  • MK-591
19 Ki 2 EC50
  • 5-hydroxytryptamine receptor 3A
  • Adrenergic receptor alpha-2
  • Adrenergic receptor beta
  • Alpha-1A adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • HTR4
  • Serotonin (5-HT) receptor
  • Serotonin 1 (5-HT1) receptor
  • Serotonin 2 (5-HT2) receptor
  • Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor
  • Serotonin 4 (5-HT4) receptor
  • 4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-2-((R)-methoxy)-benzamide
  • 4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-benzamide
  • 4-Amino-N-(R)-1-aza-bicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxy-benzamide
  • CHEMBL27846
  • ZACOPRIDE,S
21 IC50
  • ALK tyrosine kinase receptor
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor 2
  • Hepatocyte growth factor receptor
  • Platelet-derived growth factor receptor alpha
  • Platelet-derived growth factor receptor beta
  • Proto-oncogene tyrosine-protein kinase Src
  • RAC-alpha serine/threonine-protein kinase
  • Receptor protein-tyrosine kinase erbB-4
  • Receptor tyrosine-protein kinase erbB-2
  • Serine/threonine-protein kinase AKT2
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase SYK
  • Tyrosine-protein kinase receptor FLT3
  • CHEMBL3357634
9 Ki 9 IC50 3 EC50
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 3A
  • 5-hydroxytryptamine receptor 4 (5-HT4)
  • Adenosine receptor A2b
  • Adrenergic receptor alpha-1
  • D(2) dopamine receptor
  • Histamine H1 receptor
  • Muscarinic acetylcholine receptor M4
  • Serotonin (5-HT) receptor
  • Serotonin 2 (5-HT2) receptor
  • 2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-tolyl-piperazin-1-yl)-ethanone
  • CHEMBL120055
  • CHEMBL321818
20 IC50 1 EC50
  • Arachidonate 5-lipoxygenase
  • Cyclooxygenase
  • Cyclooxygenase-1 (COX-1)
  • Prostaglandin E synthase
  • Prostaglandin E synthase/G/H synthase 2
  • Prostaglandin G/H synthase (cyclooxygenase)
  • 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetic acid
  • CHEMBL300982
  • Licofelone
  • ML-3000
  • [2-(4-Chloro-phenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl]-acetic acid
  • [6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZIN-5-YL]ACETIC ACID
21 IC50
  • Aurora kinase A/Targeting protein for Xklp2
  • Aurora kinase B
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Serine/threonine-protein kinase PLK4
  • Tyrosine-protein kinase receptor FLT3
  • Vascular endothelial growth factor receptor 2
  • CHEMBL3353348
  • US10358436, Example A35
  • US9907800, Example A35
21 IC50
  • Aurora kinase B
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Serine/threonine-protein kinase PLK4
  • Tyrosine-protein kinase receptor FLT3
  • Vascular endothelial growth factor receptor 2
  • CHEMBL3353341
  • US10358436, Example A33
  • US9907800, Example A33
16 IC50 5 EC50
  • 5-lipoxygenase/FLAP
  • Calcium dependent protein kinase
  • Glyoxalase I
  • Lymphocyte differentiation antigen CD38
  • Myosin light chain kinase, smooth muscle
  • Serine/threonine-protein kinase 33
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase SYK
  • mRNA interferase toxin, antitoxin is MazE
  • (E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol
  • (E)-Piceatannol
  • 3,3',4,5'-tetrahydroxystilbene
  • 3,4,3',5'-tetrahydroxy-trans-stilbene
  • 3,4,3',5'-tetrahydroxystillbene
  • 4-(3,5-dihydroxystyryl)benzene-1,2-diol
  • 4-[(E)-2-(3,5-dihydroxyphenyl)vinyl]benzene-1,2-diol
  • 4-[(E)-2-(3,5-dihydroxyphenyl)vinyl]benzene-1,2-diol(Piceatannol)
  • 4-[2-(3,5-dihydroxyphenyl)-(E)-1-ethenyl]-1,2-benzenediol
  • 4-[2-(3,5-dihydroxyphenyl)-(E)-1-ethenyl]-1,2-benzenediol(Piceatannol)
  • CHEMBL69863
  • NSC-365798
  • cid_667639
  • piceatanol
  • trans-3,3',4,5'-tetrahydroxystilbene
8 Ki 13 IC50
  • Monoamine transporters; Norepininephrine & dopamine
  • Norepinephrine Monoamine transporters
  • Sodium-dependent dopamine transporter
  • Sodium-dependent serotonin transporter
  • 3-(4-Fluoro-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester
  • 3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester
  • CHEMBL80515
21 Ki
  • GABA A receptor alpha-5/beta-3/gamma-2
  • GABA A receptor alpha-6/beta-2/gamma-2
  • GABA receptor alpha-1/beta-3/gamma-2 subunit
  • GABA receptor alpha-2/beta-2/gamma-2 subunit
  • GABA receptor alpha-2/beta-3/gamma-2 subunit
  • GABA receptor alpha-3/beta-2/gamma-2 subunit
  • GABA receptor alpha-3/beta-3/gamma-2 subunit
  • GABA receptor alpha-4/beta-3/gamma-2 subunit
  • GABA receptor alpha-5/beta-3/gamma-2 subunit
  • GABA receptor alpha-6/beta-3/gamma-2 subunit
  • GABA-A receptor; alpha-1/beta-2/gamma-2
  • 5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid tert-butyl ester
  • 5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid tert-butyl ester(RY 23)
  • CHEMBL300840
  • RY 24
7 Ki 14 IC50
  • Dipeptidyl peptidase 2 (DPP II)
  • Dipeptidyl peptidase 4
  • Dipeptidyl peptidase 9
  • Dipeptidyl peptidase VIII
  • Prolyl endopeptidase
  • (R)-1-((S)-2-aminopropanoyl)pyrrolidin-2-ylboronic acid
  • Boronic acid derivative
  • CHEMBL63860
  • US8933056, Ala-boroPro
  • US8933056, Asp-boroPro
4 Ki 17 IC50
  • EDNRA
  • EDNRB
  • Endothelin receptor ET-B
  • Endothelin receptor, ET-A/ET-B
  • Endothelin-1 receptor
  • (2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid
  • 4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid
  • A-127722
  • CHEMBL9194
4 Ki 9 IC50 8 EC50
  • Metabotropic glutamate receptor
  • Metabotropic glutamate receptor 1
  • Metabotropic glutamate receptor 2
  • Metabotropic glutamate receptor 4 (mGlu4)
  • Metabotropic glutamate receptor 4 (mGluR4)
  • Metabotropic glutamate receptor 5
  • (S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-1-carboxylic acid
  • 3-((S)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane-1-carboxylic acid
  • 3-(Amino-carboxy-methyl)-bicyclo[1.1.1]pentane-1-carboxylic acid(S-CBPG)
  • 3-[amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acid
  • CHEMBL43412
9 Ki 12 EC50
  • 5-hydroxytryptamine receptor 1A
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • (R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-ij]quinolin-2-one
  • CHEMBL419792
  • PNU-95666E
16 IC50 5 EC50
  • 5-hydroxytryptamine receptor 1A (5HT1A)
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 3A
  • Serotonin (5-HT) receptor
  • 3-(3-{4-[2-(3-Fluoro-phenyl)-ethyl]-piperazin-1-yl}-propyl)-5-[1,2,4]triazol-4-yl-1H-indole
  • 3-[3-[4-[2-(3-fluorophenyl)ethyl]-1-piperazinyl]propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indole
  • CHEMBL292779
  • L-775606
21 Ki
  • Cholinergic, Nicotinic Alpha3Beta2
  • Neuronal acetylcholine receptor
  • Neuronal acetylcholine receptor subunit alpha-2
  • Neuronal acetylcholine receptor subunit alpha-3
  • Neuronal acetylcholine receptor subunit alpha-4
  • Neuronal acetylcholine receptor; alpha2/beta2
  • n-AChR
  • (+)Methyl-(2,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amine
  • (+/-)Methyl-(2,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amine
  • (-)Methyl-(2,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amine
  • CHEMBL267936
  • MECAMYLAMINE
  • Methyl-(2,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amine
  • Methyl-(2,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amine(Mecamylamine)
8 Ki 4 IC50 9 EC50
  • Adrenergic alpha1B
  • Adrenergic receptor alpha-2
  • Adrenergic receptor beta
  • Alpha adrenergic receptor 1A and 1B
  • Alpha adrenergic receptor 1A and 1D
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • Alpha-1A adrenergic receptor
  • Cerebral cortex alpha adrenergic receptor
  • Reverse transcriptase
  • adrenergic Alpha1
  • CHEBI:8093
  • Cyclomydril
  • Duo-Medihaler
  • PHENYLEPHRINE
  • Phenylephrine
17 IC50 4 EC50
  • Cholecystokinin receptor
  • CHEMBL156605
1 Ki 10 IC50 10 EC50
  • Arachidonate 5-lipoxygenase
  • G-protein coupled receptor 84
  • Histone acetyltransferase PCAF
  • Macrophage-expressed gene 1 protein
  • Prostaglandin E synthase
  • X-linked inhibitor of apoptosis protein (XIAP)
  • CHEBI:4778
  • EMBELIN
  • Embelin
21 Ki
  • Carbonic Anhydrase IV
  • Carbonic anhydrase
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • 6-Amino-benzothiazole-2-sulfonic acid amide
  • 6-aminobenzo[d]thiazole-2-sulfonamide
  • CHEMBL35118
12 Ki 9 IC50
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Potassium voltage-gated channel subfamily H member 2
  • CHEMBL3422007
  • US10065961, Compound 30
  • US10683295, Compound 30
  • US9475814, 30
1 Ki 20 IC50
  • Dual specificity protein phosphatase (VHR)
  • Dual specificity protein phosphatase 23 (VHZ)
  • Dual specificity protein phosphatase CDC14A
  • Hematopoietic protein-tyrosine phosphatase (HEPTP)
  • Laforin
  • Low molecular weight phosphotyrosine protein phosphatase
  • Mitogen-activated protein kinase phosphatase 5 (MKP5)
  • Nuclear proteasome inhibitor UBLCP1
  • Protein phosphatase 5 (PP5)
  • Protein-tyrosine phosphatase 1B
  • Protein-tyrosine phosphatase 1C
  • Protein-tyrosine phosphatase pez
  • Receptor-type tyrosine-protein phosphatase F (LAR)
  • Receptor-type tyrosine-protein phosphatase epsilon (PTPε)
  • Receptor-type tyrosine-protein phosphatase gamma
  • Tyrosine-protein phosphatase non-receptor type 11
  • Tyrosine-protein phosphatase non-receptor type 2
  • Tyrosine-protein phosphatase non-receptor type 3 (PTPH1)
  • carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
  • tyrosine-protein phosphatase non-receptor type 5 isoform a
  • CHEMBL3426913
21 Ki
  • Adenosine A1 receptor
  • Adenosine Receptors A2a (A2a)
  • Adenosine receptor A1
  • Adenosine receptor A2a
  • Adenosine receptor A2a and A3
  • Adenosine receptor A2b
  • Adenosine receptor A3
  • (2R,3R,4S,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol
  • 2-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol
  • CHEMBL307199
21 Ki
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 7
  • D(2) dopamine receptor
  • Serotonin (5-HT) receptor
  • Sodium-dependent serotonin transporter
  • (6aR,aR)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-yl)-benzonitrile
  • (6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-yl)-benzonitrile
  • 3-Methyl-2-((R)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-yl)-benzonitrile
  • CHEMBL28056
21 IC50
  • Nitric Oxide Synthase, endothelial
  • Nitric Oxide Synthase, inducible
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Nitric oxide synthase, inducible
  • Nitric-oxide synthase, brain
  • (S)-methyl 2-amino-5-(amino(nitroamino)methyleneamino)pentanoate
  • CHEMBL1256014
  • CHEMBL7890
  • L-NAME
  • N(gamma)-Nitro-L-arginine methyl ester
  • N-.omega.-Nitro-O-arginine methyl ester
  • N-omega-nitro-L-arginine methyl ester
  • methyl (2S)-2-amino-5-{[(E)-imino(nitroamino)methyl]amino}pentanoate
  • methyl (2S)-2-amino-5-{[(Z)-imino(nitroamino)methyl]amino}pentanoate
  • nitro-L-arginine methyl ester
21 Ki
  • Delta-type opioid receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Opioid receptors; mu & delta
  • 3-(4-Hydroxy-phenyl)-N-{(S)-1-[(3R,4R)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-ylmethyl]-2-methyl-propyl}-propionamide
  • 3-(4-Hydroxy-phenyl)-N-{1-[4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-ylmethyl]-2-methyl-propyl}-propionamide
  • CHEMBL10986
14 Ki 7 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • Bile salt export pump
  • Cytochrome P450 2C8
  • Indoleamine 2,3-dioxygenase
  • Lysine-specific histone demethylase 1A
  • Monoamine Oxidase Type B (MAO-B)
  • Monoamine oxidase
  • Sodium-dependent dopamine transporter
  • Sodium-dependent noradrenaline transporter
  • Sodium-dependent serotonin transporter
  • Vascular adhesion protein 1 (VAP-1)
  • CHEMBL1089
  • Nardil
  • PHENELZINE
  • Phenethyl-hydrazine
21 EC50
  • Baculoviral IAP repeat-containing protein 2/Estrogen receptor
  • Estradiol receptor beta (ERβ)
  • Estrogen receptor
  • (+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile
  • 2,3-Bis-(4-hydroxy-phenyl)-propionitrile
  • 2,3-bis(4-hydroxyphenyl)propanenitrile
  • CHEMBL334773
  • DIARYLPROPIONITRILE
10 IC50 11 EC50
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Genome polyprotein
  • Human rhinovirus A protease
  • Nuclear receptor subfamily 1 group I member 2
  • VP1 capsid protein
  • 3-(3,5-dimethyl-4-(3-(3-methylisoxazol-5-yl)propoxy)phenyl)-5-(trifluoromethyl)-1,2,4-oxadiazole
  • 3-{3,5-Dimethyl-4-[3-(3-methyl-isoxazol-5-yl)-propoxy]-phenyl}-5-trifluoromethyl-[1,2,4]oxadiazole
  • 3-{3,5-Dimethyl-4-[3-(3-methyl-isoxazol-5-yl)-propoxy]-phenyl}-5-trifluoromethyl-[1,2,4]oxadiazole(Pleconaril)
  • 5-[3-[2,6-dimethyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenoxy]propyl]-3-methylisoxazole
  • CHEMBL29609
  • Pleconaril
  • Pleconaril3-{3,5-Dimethyl-4-[3-(3-methyl-isoxazol-5-yl)-propoxy]-phenyl}-5-trifluoromethyl-[1,2,4]oxadiazole
4 Ki 17 EC50
  • P2X purinoceptor 1
  • P2X purinoceptor 2
  • P2X purinoceptor 3
  • P2X purinoceptor 4
  • P2X purinoceptor 5
  • P2X purinoceptor 6
  • P2Y purinoceptor 1
  • Purinergic receptor P2Y1
  • Purinergic receptor P2Y11
  • Purinergic receptor P2Y12
  • Purinergic, P2X2
  • Pyrimidinergic receptor P2Y6
  • S-adenosylmethionine synthetase (MAT 1 and MAT 2)
  • 2-MeSATP
  • ATP, 2-meS
  • CHEMBL336208
13 Ki 8 EC50
  • Adrenergic alpha1B
  • Adrenergic receptor alpha
  • Alpha adrenergic receptor 1A and 1B
  • Alpha adrenergic receptor 1A and 1D
  • Alpha-1A adrenergic receptor
  • Alpha-1D adrenergic receptor
  • Alpha-2A adrenergic receptor
  • adrenergic Alpha1
  • ABT-866
  • CHEMBL326702
  • Ethanesulfonic acid [3-(1H-imidazol-4-ylmethyl)-phenyl]-amide
  • N-(3-((1H-imidazol-4-yl)methyl)phenyl)ethanesulfonamide
  • N-[3-(1H-imidazol-4-ylmethyl)-phenyl]ethanesulfonamide
19 Ki 1 IC50 1 EC50
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • Alpha-1A adrenergic receptor
  • Alpha-2A adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • Benzofuran-2-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide
  • CHEMBL124444
  • N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)benzofuran-2-carboxamide
21 Ki
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2C
  • ADRA1B
  • Alpha-1D adrenergic receptor
  • Cerebral cortex alpha adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • Histamine H1 receptor
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
  • 1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
  • CHEMBL319352
1 Ki 16 IC50 1 Kd 3 EC50
  • Cytochrome P450 1A
  • Cytochrome P450 2B6
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • Indoleamine 2,3-dioxygenase
  • Tryptophan 2,3-dioxygenase
  • CHEMBL3629569
  • US10155972, Compound NewLink 1
  • US10233190, Example 1304
21 Ki
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 7
  • Adrenergic receptor alpha-1
  • Adrenergic receptor alpha-2
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • Alpha-2A adrenergic receptor
  • Alpha-2B adrenergic receptor
  • Alpha-2C adrenergic receptor
  • D(2) dopamine receptor
  • Histamine H1 receptor
  • Monoamine transporters; Norepininephrine & dopamine
  • Norepinephrine Monoamine transporters
  • Sodium-dependent dopamine transporter
  • Sodium-dependent serotonin transporter
  • 4-(5-Fluoro-indan-2-ylmethyl)-4,5-dihydro-1H-imidazole
  • CHEMBL90997
  • S-34324
9 Ki 12 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine-specific histone demethylase 1A (LSD1)
  • Lysine-specific histone demethylase 1A
  • CHEMBL3759239
  • US10329256, Example 5
  • US9487512, 5
  • US9944601, Example 5
20 IC50 1 EC50
  • Mono [ADP-ribose] polymerase PARP16
  • Poly [ADP-ribose] polymerase 1
  • Poly [ADP-ribose] polymerase 10
  • Poly [ADP-ribose] polymerase 14
  • Poly [ADP-ribose] polymerase 15
  • Poly [ADP-ribose] polymerase 2
  • Poly [ADP-ribose] polymerase 4
  • Poly [ADP-ribose] polymerase tankyrase-1
  • Poly [ADP-ribose] polymerase tankyrase-2
  • Protein mono-ADP-ribosyltransferase PARP3
  • CHEMBL3764816
11 IC50 10 EC50
  • Peroxisome proliferator-activated receptor
  • Peroxisome proliferator-activated receptor alpha
  • Peroxisome proliferator-activated receptor alpha (PPAR alpha)
  • Peroxisome proliferator-activated receptor delta
  • (S)-2-Methyl-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2-phenoxy-propionic acid
  • CHEMBL81248
13 IC50 8 EC50
  • 1,3-beta-glucan synthase component GLS2
  • Adrenergic receptor beta
  • Beta-1 adrenergic receptor
  • Beta-2 adrenergic receptor
  • Beta-3 adrenergic receptor
  • Calcium channel (Type L)
  • Cytochrome P450 1A
  • Cytochrome P450 2B6
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Nuclear receptor subfamily 1 group I member 2
  • Sodium channel protein type 5 subunit alpha
  • Sodium-dependent serotonin transporter
  • KRP-114V
  • MK-4618
  • VIBEGRON
  • Vibegron
21 IC50
  • Monoamine transporter
  • Monoamine transporters; Norepinephrine & serotonin
  • Monoamine transporters; Norepininephrine & dopamine
  • Neuroepithelial cell-transforming 1
  • Neuroepithelial cell-transforming gene 1 protein
  • Sodium-dependent dopamine transporter
  • Sodium-dependent noradrenaline transporter
  • Sodium-dependent serotonin transporter
  • CHEMBL3770651
  • US10562878, Compound 203
21 Ki
  • Alpha carbonic anhydrase
  • Carbonic Anhydrase VA
  • Carbonic Anhydrase XIII
  • Carbonic anhydrase
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • Carbonic anhydrase 6 (CA-VI)
  • Carbonic anhydrase 7
  • Carbonic anhydrase 9
  • CHEMBL1352
  • HONO2
  • nitric acid
2 Ki 18 IC50 1 Kd
  • 1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic
  • 1-deoxyxylulose-5-phosphate reductoisomerase
  • 3-(N-hydroxyformamido)propylphosphonic acid
  • 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID
  • CHEMBL203125
  • [3-(Formyl-hydroxy-amino)-propyl]-phosphonic acid
  • fosmidomycin
13 Ki 8 IC50
  • 1,3-beta-glucan synthase component GLS2
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M3
  • CHEMBL3774411
  • US10273244, Example 165
  • US10584135, Example 165
20 IC50 1 EC50
  • Lysine-specific demethylase 4C
  • Lysine-specific demethylase 5A
  • Lysine-specific demethylase 5A/5B
  • Lysine-specific demethylase 5B
  • CHEMBL3785832
  • US10173996, Example 53
  • US9604961, Example 53
  • US9714230, 53
  • US9908865, Example 53
21 IC50
  • Bacteriophage T4 DNA Ligase
  • CAM-RNase A
  • DNA topoisomerase
  • DNA topoisomerase 1
  • DNA topoisomerase I
  • DNA topoisomerase I (Topo I)
  • Deoxyribonuclease-1
  • Deoxyribonuclease-2-alpha
  • Telomerase reverse transcriptase
  • Topoisomerase II alpha (HuTopoIIα)
  • Type-2 restriction enzyme BamHI
  • Type-2 restriction enzyme EcoRI
  • Type-2 restriction enzyme HindIII
  • Type-2 restriction enzyme PstI
  • Type-2 restriction enzyme ScaI
  • 6-Hydroxy-3-[1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-3H-benzofuran-2-one
  • CHEMBL195416
  • isoaurostatin
10 Ki 10 IC50 1 EC50
  • 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
  • 5-hydroxytryptamine receptor 1A
  • Anti-estrogen binding site (AEBS)
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • Glutamate receptor ionotropic, NMDA 1
  • Sigma non-opioid intracellular receptor 1
  • Sodium-dependent dopamine transporter
  • Sodium-dependent serotonin transporter
  • CHEMBL190883
  • CHEMBL521582
  • N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine
  • N-(4-methoxy-3-phenethoxyphenethyl)-N-propylpropan-1-amine
  • NE-100
  • [2-(4-Methoxy-3-phenethyloxy-phenyl)-ethyl]-dipropyl-amine
18 Ki 3 IC50
  • Amphiregulin
  • Disintegrin and metalloproteinase domain-containing protein 17
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Stromelysin-1
  • ((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid ethyl ester
  • CHEMBL363424
21 Ki
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 6
  • 5-hydroxytryptamine receptor 7
  • D(1A) dopamine receptor
  • D(1B) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • Delta-type opioid receptor
  • Histamine H1 receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M3
  • Muscarinic acetylcholine receptor M4
  • Muscarinic acetylcholine receptor M5
  • 4-(4-Fluoro-phenyl)-piperazine-1-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide
  • CHEMBL194206
21 Ki
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 6
  • 5-hydroxytryptamine receptor 7
  • D(1A) dopamine receptor
  • D(1B) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • Delta-type opioid receptor
  • Histamine H1 receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M3
  • Muscarinic acetylcholine receptor M4
  • Muscarinic acetylcholine receptor M5
  • 4-(4-Chloro-phenyl)-piperazine-1-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide
  • CHEMBL372453
21 Ki
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 6
  • 5-hydroxytryptamine receptor 7
  • D(1A) dopamine receptor
  • D(1B) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • Delta-type opioid receptor
  • Histamine H1 receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M3
  • Muscarinic acetylcholine receptor M4
  • Muscarinic acetylcholine receptor M5
  • 4-(2-Fluoro-phenyl)-piperazine-1-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide
  • CHEMBL196169
21 Ki
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 6
  • 5-hydroxytryptamine receptor 7
  • D(1A) dopamine receptor
  • D(1B) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • Delta-type opioid receptor
  • Histamine H1 receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M3
  • Muscarinic acetylcholine receptor M4
  • Muscarinic acetylcholine receptor M5
  • 4-(4-Methylsulfanyl-phenyl)-piperazine-1-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide
  • CHEMBL197796
21 Ki
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 6
  • 5-hydroxytryptamine receptor 7
  • D(1A) dopamine receptor
  • D(1B) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • Delta-type opioid receptor
  • Histamine H1 receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M3
  • Muscarinic acetylcholine receptor M4
  • Muscarinic acetylcholine receptor M5
  • 4-(2-Chloro-phenyl)-piperazine-1-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide
  • CHEMBL370128
21 Ki
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 6
  • 5-hydroxytryptamine receptor 7
  • D(1A) dopamine receptor
  • D(1B) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • Delta-type opioid receptor
  • Histamine H1 receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M3
  • Muscarinic acetylcholine receptor M4
  • Muscarinic acetylcholine receptor M5
  • 4-Biphenyl-4-yl-piperazine-1-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide
  • CHEMBL197408
21 Ki
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 6
  • 5-hydroxytryptamine receptor 7
  • D(1A) dopamine receptor
  • D(1B) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • Delta-type opioid receptor
  • Histamine H1 receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M3
  • Muscarinic acetylcholine receptor M4
  • Muscarinic acetylcholine receptor M5
  • 4-(4-Trifluoromethyl-phenyl)-piperazine-1-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide
  • CHEMBL196598
21 IC50
  • Neuraminidase
  • Sialidase 1
  • Sialidase 2
  • Sialidase 3
  • Sialidase 4
  • CHEMBL3819510
21 IC50
  • Neuraminidase
  • Sialidase 1
  • Sialidase 2
  • Sialidase 3
  • Sialidase 4
  • CHEMBL3818654
18 Ki 2 IC50 1 Kd
  • 5-HT2
  • Acetylcholinesterase
  • Butyrylcholinesterase (BuChE)
  • D(1A) dopamine receptor
  • D(1B) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • 16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaene
  • 3-methoxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine
  • 6-methoxy-11-methyl-11-aza-tricyclo[12.4.0.0.3,8]octadeca-1(18),3(8),4,6,14,16-hexaene
  • CHEMBL380330
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